Hyperlipidaemia and hypercholesterolaemia are risk factors of atherosclerosis and cardiovascular disease. The reference range of lipids during pregnancy has not yet been clearly set. This study sought to measure lipid parameters and pentraxin (PTX) 3 levels in low-risk pregnant women. The participants had serial blood samples taken between their 6th-9th week, 10th-13th week, 14th-19th week, 24th-29th week and 35th-40th week (as long as there were no contractions), during the labour period, and 2 days after delivery. The same tests were carried out on cord blood after delivery. There were 116 participants, of which 72 were included in the study and 44 were excluded. Total-c, HDL-c, LDL-c, TG and PTX3 increased as the pregnancy progressed. During labour, Total-c, HDL-c, LDL-c and PTX3 increased, but TG decreased. After delivery, TG and PTX3 increased but other parameters decreased from the value measured during the 35th-40th week. This study measured changes in lipid profiles and PTX3 during pregnancy, labour and after delivery, establishing a foundation for future studies.
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http://dx.doi.org/10.1080/01443615.2017.1291596 | DOI Listing |
Int Immunopharmacol
December 2024
Laboratory of Neurodegenerative Diseases and Neuroinjury Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China; MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:
Astrocyte-mediated neuroinflammation plays a key role in Parkinson's disease (PD) progression. The proinflammatory protein S100A9 is linked to various neurodegenerative diseases, but its involvement in astrocyte activation in PD remains unclear. Here, we investigate the role of S100A9 in astrocyte-mediated neuroinflammation in PD.
View Article and Find Full Text PDFHeart Lung
December 2024
Department of Respiratory and Critical Care Medicine, Mingguang People's Hospital, no.379 Mingguang Avenue, Mingguang City, Chuzhou City, 239400 Anhui Province, PR China. Electronic address:
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory illness. Pentraxin-3 (PTX3) is abnormally elevated in the plasma of patients with acute exacerbation of COPD. However, the role and significance of PTX3 in the clinical diagnosis of COPD remain unclear.
View Article and Find Full Text PDFCureus
November 2024
Department of Histology and Embryology, Firat University Faculty of Medicine, Elâzığ, TUR.
Introduction: In this study, we aimed to investigate whether hydroxytyrosol (HT) has a protective effect on corn syrup-induced kidney damage in rats and the role of podocalyxin (PCX) and pentraxin-3 (PTX3) in this possible effect.
Methods: Rats were divided into four groups with six rats in each group: 1) control, 2) HT, 3) corn syrup, and 4) corn syrup + HT. Rats were given 30% corn syrup added to their drinking water for six weeks.
J Inflamm Res
December 2024
Aier Academy of Ophthalmology, Central South University, Changsha, People's Republic of China.
Purpose: In this study, we aimed to investigate the relationship between the intraocular levels of inflammatory factors and myopia-related retinal vascular and neuronal degeneration.
Patients And Methods: One hundred and forty-seven patients with Implantable Collamer Lens (ICL) implantation were enrolled and all participants received comprehensive ophthalmic examination. About 100~150 ul of aqueous humor was collected immediately before ICL surgery.
Mol Biomed
December 2024
Department of Organ Transplantation, School of Medicine, Organ Transplantation Clinical Medical Center of Xiamen University, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, 361102, China.
The liver plays a crucial role in the immune response during endotoxemia and is one of the critical targets for sepsis-related injuries. As a secretory factor involved in inflammation, pentraxin-3 (PTX3) has been demonstrated to regulate hepatic homeostasis; however, the relationship between PTX3 and cell crosstalk between immune cells and hepatocytes in the liver remains incompletely understood. In this study, we revealed that, compared with WT mice, Ptx3 mice with lipopolysaccharide (LPS)-induced endotoxemia exhibited alleviated liver damage, with reduced serum alanine transaminase and aspartate transaminase levels and an improved survival rate.
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