The distribution of carbonic anhydrase (CA) and Na+/K+-ATPase was studied histochemically in the pecten of the fowl by light and electron microscopy. No Na+/K+-ATPase activity was seen by the method used here. CA staining was seen in the membranes of the apical and basal microvilli of the endothelial cells, while the cytoplasm took no stain. There were no staining differences between the capillaries of the different regions of the pecten. Only the capillaries of the bridge showed no microvilli and no staining. Neither did arterioles and venules which lacked microvilli stain. The functional significance of the association of CA activity and microvilli is not clear.
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http://dx.doi.org/10.1016/0014-4835(88)90031-0 | DOI Listing |
Plants (Basel)
January 2025
Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Viale delle idee 30, 50019 Sesto Fiorentino, Florence, Italy.
Global changes and growing demands have led to the development of new molecular approaches to improve crop physiological performances. Carbonic anhydrase (CA) enzymes, ubiquitous across various life kingdoms, stand out for their critical roles in plant photosynthesis and water relations. We hypothesize that the modulators of human CAs could affect plant physiology.
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley 72511, Egypt.
The present study aims to create spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives with anticancer activities. The in vitro anticancer evaluation showed that only the novel spiro-acenaphthylene tethered-[1,3,4]-thiadiazole (compound ) exhibited significant anticancer efficacy as a selective inhibitor of tumor-associated isoforms of carbonic anhydrase. Compound demonstrated considerable efficacy against the renal RXF393, colon HT29, and melanoma LOX IMVI cancer cell lines, with IC values of 7.
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January 2025
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia. Electronic address:
Multi-drug-resistant (MDR) pathogens represent a critical global health threat, necessitating the development of novel antimicrobial agents with broad-spectrum activity and minimal toxicity. This study investigates the antimicrobial and anti-biofilm properties of 4-Allyl-2-methoxyphenol (eugenol, EU) and (E)-3-Phenylprop-2-enal (cinnamaldehyde, CN) against 19 clinically significant pathogens through a combination of in-vitro assays and in-silico analyses. EU displayed remarkable activity, particularly against Aspergillus niger (20.
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Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization, Hubei Engineering Research Center of Special Wild Vegetables Breeding and Comprehensive Utilization Technology, College of life sciences, Hubei Normal University, Huangshi 435002, Hubei, China. Electronic address:
Prioritizing defense over growth often occurs under ultraviolet (UV)-B radiation while several studies showed its growth-promoting effects on photosynthetic organisms, how they overcome the growth-defense trade-off is unclear. This study deciphered the acclimation responses of the cyanobacterium Nostoc sphaeroides to low UV-B radiation (0.08 W m) using quantitative proteomic, physiological and biochemical analyses.
View Article and Find Full Text PDFMar Drugs
December 2024
Graduate Program in Biochemistry and Molecular Biology, Center of Biosciences, Federal University of Rio Grande do Norte-UFRN, Av. Sen. Salgado Filho, 3000, Natal 59078-900, Brazil.
Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated. This study aimed to employ computational tools to investigate the pharmacological properties and molecular targets pertinent to cancer of the disaccharides derived from the primary carrageenans.
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