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Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine.
Annu Rev Pathol
January 2025
MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA; email:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem, affecting ∼1 billion people. This condition is well established to have a heritable component with strong familial clustering. With the extraordinary breakthroughs in genetic research techniques coupled with their application to large-scale biobanks, the field of genetics in MASLD has expanded rapidly.
View Article and Find Full Text PDFTransplantation of the MSLN-deficient Thymus Generates MSLN Epitope Reactive T Cells to Attenuate Tumor Progression.
Cancer Sci
January 2025
Department of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
The development of mesothelin (MSLN) epitope reactive T cells is observed in mice that are immunized with the MSLN vaccine. Engineered T cells expressing MSLN-reactive high-affinity TCR exhibit extraordinary therapeutic effects for invasive pancreatic ductal adenocarcinoma in a mouse model. However, the generation of MSLN-reactive T cells through the introduction of MSLN-deficient thymus and the transplantation of the latter as a cure for cancer treatment have not been tested to date.
View Article and Find Full Text PDFPublic Health Travel Restrictions Implemented for Persons at Risk of Transmitting SARS-CoV-2 Infection-United States, January 1, 2020-April 6, 2022.
J Public Health Manag Pract
January 2025
Author Affiliations: Division of Global Migration Health, Centers for Disease Control and Prevention (Ms Surpris, Ms Jungerman, Dr Preston, Dr Gertz, Ms Duong, Dr Roy, Ms Morales, Mr Olmstead, Ms Delea, Dr Alvarado-Ramy, Dr Brown, and Dr Chen); Council of State and Territorial Epidemiologist (CSTE) Fellow, Atlanta, Georgia (Mr Olmstead); and University of South Florida, Tampa, Florida (Ms Surpris).
Context: Federal public health travel restrictions (FPHTR) in the United States are implemented for persons who meet specific criteria to prevent spread of communicable diseases of public health concern. FPHTR can mitigate the risk of disease transmission during air travel and mitigating disease translocation between geographic areas.
Objective: To characterize and determine the extent of FPHTR implementation during the COVID-19 pandemic.
Plasmonic Single-Molecule Affinity Detection at 10 Molar.
Adv Mater
January 2025
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, 70125, Italy.
DNA can be readily amplified through replication, enabling the detection of a single-target copy. A comparable performance for proteins in immunoassays has yet to be fully assessed. Surface-plasmon-resonance (SPR) serves as a probe capable of performing assays at concentrations typically around 10⁻⁹ molar.
View Article and Find Full Text PDFEcomorphological correlates of grasping forces in strepsirrhine primates.
Proc Biol Sci
January 2025
Department of Anatomy, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Powerful digital grasping is essential for primates navigating arboreal environments and is often regarded as a defining characteristic of the order. However, data on primate grip strength are limited. In this study, we collected grasping data from the hands and feet of eleven strepsirrhine species to assess how ecomorphological variables-such as autopodial shape, laterality, body mass and locomotor mode-influence grasping performance.
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