Whole Genome-Based Amplified Fragment Length Polymorphism Analysis Reveals Genetic Diversity in .

This study aimed at investigating the genetic diversity of a panel of strains recovered from vaginal samples in different countries. All fungal strains were heterozygous at the mating-type-like locus and belonged to the genotype A of . Moreover, all examined strains lack -acetylglucosamine assimilation and sequence analysis of the gene showed a distinctive polymorphism that impair the utilization of this amino sugar in this yeast. Multi-locus sequencing of seven housekeeping genes revealed a substantial genetic homogeneity among the strains, except for the and loci which contributed significantly to the classification of our set of strains into six existing diploid sequence types. Amplified fragment length polymorphism fingerprint analysis yielded greater genotypic heterogeneity among the strains. Overall the data reported here show that in genetic diversity occurs and the existence of this intriguing group of strains with specific phenotypes associated could be useful for future comparative studies in order to better understand the genetics and evolution of this important human pathogen.