The history of the acyl-quinic acids is briefly reviewed, the merits and limitations of the various nomenclature systems applicable are critically compared, and their limitations are highlighted, in particular their inability to provide an unambiguous description of all quinic acid enantiomers and diastereoisomers and associated acyl-quinic acids. Recommendations are made for a nomenclature system that in combination with IUPAC numbering achieves this objective. A comprehensive set of structures for the quinic acid enantiomers and diastereoisomers is presented. The Supporting Information provides an explanation of trivial names and a decision tree to determine which quinic acid isomer a structure represents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jafc.7b00729 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioactivities of Quinic Acids from Obtained by Supercritical Fluid Extraction.
Antioxidants (Basel)
October 2024
College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon 57922, Jeonnam, Republic of Korea.
Acyl-quinic acids (AQAs), present in various plants with many health benefits, are regarded as therapeutic agents in the prevention and treatment of chronic and cardiovascular diseases. The molecular network-guided identification of ten AQA compounds, two new ( and ) and eight known compounds, were isolated from L. f.
View Article and Find Full Text PDFMetabolic profiling of Vitex Pubescens Vahl bark via UPLC-ESI-QTOF/MS/MS analysis and evaluation of its antioxidant and acetylcholinesterase inhibitory activities.
BMC Complement Med Ther
June 2024
Pharmacognosy Department, Faculty of Pharmacy, The British University in Egypt, Cairo, 11837, Egypt.
Article Synopsis
- - Alzheimer's disease causes severe memory loss and is a leading cause of disability in older adults, with multiple complex factors contributing to its progression, including the buildup of β-amyloid plaques and neuroinflammation.
- - Traditional treatments like donepezil only manage symptoms without stopping progression and can have significant side effects, leading researchers to explore natural alternatives for a more holistic approach.
- - This study found various metabolites in Vitex pubescens bark, with a focus on phenolic compounds, and evaluated its antioxidant properties and effects on acetylcholinesterase, indicating potential therapeutic benefits for Alzheimer’s treatment.
Acyl-quinic acids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase and cyclooxygenase-2 in vitro.
Bioorg Chem
November 2023
Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xianyang 712083, PR China. Electronic address:
Eleven new acyl-quinic acids (AQAs) 1a-9, and 18 known AQAs 10-27 were isolated from the root bark of Acanthopanax gracilistylus W. W. Smith (Acanthopanacis Cortex).
View Article and Find Full Text PDFA Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids.
Antioxid Redox Signal
March 2024
Department of Food and Drugs, University of Parma, Parma, Italy.
Hydroxycinnamic acids (HCAs) are the main phenolic acids in the western diet. Harmonizing the available information on the absorption, distribution, metabolism, and excretion (ADME) of HCAs is fundamental to unraveling the compounds responsible for their health effects. This work systematically assessed pharmacokinetics, including urinary recovery, and bioavailability of HCAs and their metabolites, based on literature reports.
View Article and Find Full Text PDFIn vivo study of the bioavailability and metabolic profile of (poly)phenols after sous-vide artichoke consumption.
Food Chem
January 2022
Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Science and Medicine, King's College London, London, UK. Electronic address:
Artichokes are a rich source of (poly)phenols, mainly caffeoylquinic acids, but little is known about their bioavailability from this source. This study investigated the absorption, metabolism and excretion of (poly)phenols after sous-vide artichoke consumption (5776 µmol of (poly)phenols) by healthy volunteers. Seventy-six (poly)phenol metabolites were identified by UHPLC-MS/MS using authentic standards, including acyl-quinic acids plus C-C, C-C, C-C, C-C-N, C-C metabolites, and their phase-II conjugates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!