AI Article Synopsis
- - A study on the shells of a plant species from the Apocynaceae family led to the discovery of three new pregnane steroids, named metajapogenins A-C.
- - The chemical structures of these new compounds were determined using advanced techniques like 1D and 2D NMR spectroscopy and mass spectrometry.
- - Additionally, three known compounds were identified in the shells for the first time, including pergularin and its derivatives.
Article Abstract
Phytochemical investigation of the shells of (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A-C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12--acetylpergularin; and pergularin-3--β-d-oleandropyranose; which were identified for the first time in the shells of . .
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154641 | PMC |
| http://dx.doi.org/10.3390/molecules22040646 | DOI Listing |
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Metajapogenins A-C, Pregnane Steroids from Shells of Metaplexis japonica.
Molecules
April 2017
School of Pharmacy, Qingdao University, Qingdao 266021, Shandong, China.
Phytochemical investigation of the shells of (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A-C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry.
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