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| http://dx.doi.org/10.1177/1352458517704924 | DOI Listing |
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The human patellar tendon is mechanically homogenous at its mid-substance.
J Mech Behav Biomed Mater
December 2024
Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.
The human patellar tendon contains distinct fascicle bundles across its mediolateral and anteroposterior regions. Studies have suggested region-specific behaviour during in vivo actions, but it is unclear whether such regional differences result from localized variation in composition and mechanical properties within the tendon itself. Furthermore, the viscoelastic properties of any region of the human patellar tendon have not been well described previously.
View Article and Find Full Text PDFQuantifying intestinal lipolysis with MRI and TD-NMR: Proof of concept using dairy cream digested in vitro.
Food Chem
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INRAE, OPAALE, 35044 Rennes, France. Electronic address:
Understanding lipid digestion is crucial for promoting human health. Traditional methods for studying lipolysis face challenges in sample representativeness and pre-treatment, and cannot measure real-time lipolysis in vivo. Thus, non-invasive techniques like magnetic resonance imaging (MRI) need to be developed.
View Article and Find Full Text PDFDevelopment of multifunctional fluorescence-emitting potential theranostic agents for Alzheimer's disease.
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Pharmaceutical Chemistry Research Laboratory I, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. Electronic address:
The cholinergic deficits and amyloid beta (Aβ) aggregation are the mainstream simultaneously observed pathologies during the progression of Alzheimer's disease (AD). Deposited Aβ plaques are considered to be the primary pathological hallmarks of AD and are contemplated as promising diagnostic biomarker. Herein, a series of novel theranostic agents were designed, synthesised and evaluated against cholinesterase (ChEs) enzymes and detection of Aβ species, which are major targets for development of therapeutics for AD.
View Article and Find Full Text PDFIn vivo imaging markers of glymphatic dysfunction in amyotrophic lateral sclerosis: Analysis of ALPS index and choroid plexus volume.
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Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:
Background: The glymphatic system, essential for brain waste clearance, has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Emerging imaging markers, such as the analysis along the perivascular space (ALPS) index and choroid plexus volume (CPV), may provide insights into glymphatic function, but their relevance to ALS remains unclear.
Objective: To assess glymphatic dysfunction in ALS patients using the ALPS index and CPV.
Spatially constrained hyperpolarized 13C MRI pharmacokinetic rate constant map estimation using a digital brain phantom and a U-Net.
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UC Berkeley - UCSF Graduate Program in Bioengineering, 1700 4th St, San Francisco, CA 94158, USA; Radiology and Biomedical Imaging, University of California, San Francisco, 1700 4th St, San Francisco, CA 94158, USA.
Fitting rate constants to Hyperpolarized [1-C]Pyruvate (HP C13) MRI data is a promising approach for quantifying metabolism in vivo. Current methods typically fit each voxel of the dataset using a least-squares objective. With these methods, each voxel is considered independently, and the spatial relationships are not considered during fitting.
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