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Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience. | LitMetric

AI Article Synopsis

Article Abstract

Background: Pigmented epithelioid melanocytoma (PEM) is an uncommon, recently described entity with unknown biologic behavior. There is a high rate of regional metastases, but limited evidence of distant metastases or disease-related death.

Objective: We sought to report our series of patients given a diagnosis of PEM at our institution and provide mutational analysis of genes commonly implicated in melanoma in 2 cases.

Methods: The pathology database was queried for cases of PEM diagnosed at the University of Rochester. Charts were reviewed for follow-up information. Mutational analysis of melanoma-associated genes was performed on 2 cases.

Results: Nine cases of PEM were retrieved in a 10-year retrospective review. Five patients underwent sentinel lymph node biopsy with 3 of 5 having a positive sentinel lymph node. All 9 patients are alive and disease-free with average follow-up of 38.75 months. Two tumors were tested for common melanoma-associated mutations, and were negative, except for a telomerase reverse transcriptase promoter deletion detected in 1 sample. The deletion has not been associated with melanoma, and therefore its biologic significance is unclear.

Limitations: Small sample size, retrospective nature, and single institution experience are limitations.

Conclusions: PEM appears to have an indolent behavior. However, currently the evidence is too limited to provide insight into its true biologic potential.

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Source
http://dx.doi.org/10.1016/j.jaad.2017.01.029DOI Listing

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