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Multiple liver metastases of unknown origin: A case report.
World J Gastrointest Oncol
January 2025
Department of Hepatobiliary Pancreatic Surgery, Peking University First Hospital, Beijing 100034, China.
Background: The liver is the most common site of digestive system tumor metastasis, but not all liver metastases can be traced back to the primary lesions. Although it is unusual, syphilis can impact the liver, manifesting as syphilitic hepatitis with inflammatory nodules, which might be misdiagnosed as metastasis.
Case Summary: This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three months.
Syphilitic Lymphadenitis and Clavicle Pathological Fracture Mimicking Malignant Tumor on 18F-FDG PET/CT.
Clin Nucl Med
December 2024
From the Department of Nuclear Medicine, Weifang Traditional Chinese Medicine Hospital, Shandong Second Medical University. Weifang City.
A 66-year-old woman presented with 9 days of left clavicle pain, with no history of recent trauma. CT images showed a left clavicle fracture with a surrounding soft tissue mass. An 18F-FDG PET/CT scan revealed increased FDG uptake in the tonsils, multiple lymph nodes, and the pathologically fractured clavicle, initially suggesting malignancy.
View Article and Find Full Text PDFAnalysis of Neurosyphilis Imaging Methods and Treatment: A Focused Review.
Cureus
November 2024
Medical Education, Geisinger Commonwealth School of Medicine, Scranton, USA.
Article Synopsis
- * Diagnosis relies on cerebrospinal fluid analysis and neuroimaging techniques like MRI and SPECT, and there are recent advances in testing methods and imaging to monitor treatment effectiveness.
- * The main treatment is Penicillin G, while ceftriaxone is an alternative for those allergic to penicillin; both aim to improve patient outcomes by enhancing understanding of neurosyphilis pathophysiology and refining diagnostic and treatment methods.
Development and utilization of expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
mBio
January 2025
Department of Medicine, University of Connecticut Health, Farmington, Connecticut, USA.
Article Synopsis
- Syphilis, caused by a spirochetal pathogen, can lead to serious health complications if untreated, necessitating new strategies to understand its complex pathogenesis.
- This study engineered a strain of the syphilis bacteria that expresses green fluorescent protein (GFP), allowing researchers to visualize its interactions with host cells and evaluate its infectivity in a rabbit model.
- The findings emphasize the role of specific antibody responses in targeting the bacteria's outer membrane, highlighting potential targets for protective immunity and paving the way for future research on spirochetal-host interactions.
A Case of Syphilis Associated With Genital and Extragenital Hard Chancres, Inguinal Lymphadenitis, and Systemic Symptoms.
Cureus
October 2024
Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, JPN.
Syphilis is a sexually transmitted infection caused by the spirochete (TP) subspecies . Syphilis can be transmitted via contact with infected bodily fluids, such as blood or semen, congenital infection, blood transfusion, or organ transplantation. After a brief incubation period, the disease manifests with signs and symptoms such as genital ulcers, erythematous papules on the palms and soles, fever, and lymphadenopathy.
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