Background: Exercise transcutaneous oximetry (Ex-tcPO2) is a non-invasive test for exercise-induced buttock ischemia. Prior study defined Ex-tcPO2 normal/abnormal cut-offs against arteriography but no external validation was available. The aims of this study were therefore to (1) determine the diagnostic performance of Ex-tcPO2 against CTA; (2) determine the cut-off point for detection of stenosis >75% in arteries toward the hypogastric circulation; and (3) determine the effect of chest profile classification on the diagnostic performance of Ex-tcPO2.Methods and Results:A total of 207 patients referred for Ex-tcPO2 were analyzed. DROP during Ex-tcPO2 was compared with the CTA results. Chest-tcPO2 changes were automatically classified into pre-defined profiles representing normal or abnormal responses. Using DROP <-15 mmHg as a cut-off, Ex-tcPO2 had 80.2% sensitivity, 72.3% specificity, 43.1% PPV, 93.3% NPV and 73.9% accuracy, to detect 1 stenosis >75% in arteries toward the hypogastric circulation. Optimal DROP to detect stenosis was: -15 mmHg. The overall diagnostic performance of Ex-tcPO2 was independent of chest profile classification.
Conclusions: Ex-tcPO2 has satisfactory diagnostic performance to detect arterial stenoses towards the hypogastric circulation. Abnormal chest-tcPO2 profile does not impair the overall diagnostic performance of the test.
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http://dx.doi.org/10.1253/circj.CJ-16-1316 | DOI Listing |
Purpose: To describe a surgical technique for retinal detachment (RD) with undetected retinal breaks, which combines pars plana vitrectomy (PPV) and external subretinal fluid (SRF) drainage.
Methods: In this retrospective observational study, patients with diagnosis of RD with undetected retinal breaks were enrolled. Standard three-port 25 Gauge (G) core and peripheral PPV was performed.
Chemistry
December 2024
Hebei University, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Materials Science,, CHINA.
Flexible film in display requires multi-functional integration, such as stretchability, flexibility, abrasion resistance, transparency, and shape memory. In this paper, a reasonable design strategy of flexible polyacrylate (PA) film with high transparency, shape memory, excellent abrasion resistance and foldability is presented. The PA films are prepared by free radical polymerization of vinyl-terminated polyurethane (PU) prepolymer as a cross-linking agent and acrylate monomers in ultraviolet (UV) light.
View Article and Find Full Text PDFChemMedChem
December 2024
Central China Normal University, State Key Laboratory of Green Pesticide, CHINA.
Butyrylcholinesterase plays an indispensable role in organisms, and its abnormal expression poses a significant threat to human health and safety, covering various aspects including liver-related diseases, diabetes, obesity, cardiovascular and cerebrovascular diseases, and neurodegenerative diseases. In addition, toxic substances such as organophosphorus and carbamate pesticides markedly inhibit BChE activity. BChE activity serves as a critical parameter for the clinical diagnosis of acute organophosphorus pesticide poisoning and the evaluation of organophosphorus and carbamate pesticide residues.
View Article and Find Full Text PDFEnviron Microbiol Rep
December 2024
Facultad de Ciencias de la Salud, Universidad Alfonso X el Sabio, Madrid, Spain.
Managing infections caused by multidrug-resistant Gram-negative bacilli is a major public health concern, particularly in hospitals where surfaces can act as reservoirs for resistant microorganisms. Identifying these bacteria in hospital environments is crucial for improving healthcare safety. This study aimed to analyse environmental samples from a veterinary hospital to identify prevalent microorganisms and detect antimicrobial resistance patterns.
View Article and Find Full Text PDFEur J Prev Cardiol
December 2024
Cardiovascular and Genomics Institute, City St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Aims: Sudden arrhythmic death syndrome (SADS) refers to a sudden death, which remains unexplained despite comprehensive post-mortem examination and a toxicological screen. We aimed to investigate the impact of age and sex on the overall diagnostic yield and underlying aetiology in decedents with SADS using a combined approach of familial evaluation (FE) and molecular autopsy (MA).
Methods And Results: Consecutive referrals to a single centre for FE only, MA only or both, following a SADS death were included.
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