The Institute for Drug Research, School of Pharmacy, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:
Published: August 2015
AI Article Synopsis
Article Abstract
Many polyphenols bind proteins, therefore our research was focused on the potential of protein binding to polyphenols of investigated fruits and their health-related effects. The contents of polyphenols and related antioxidant activities of traditional, citrus and exotic fruits were compared. The presence of polyphenols (flavonoids and phenolic acids) in the investigated samples and their interaction with human serum albumin (HSA) was studied by HPLC, Fourier Transform Infrared (FT-IR) and three dimensional fluorescence spectroscopy (3D-FL). The highest levels of polyphenols, antioxidant and binding capacities were found in red and blond grapefruits (citrus group), followed by strawberries and apples (traditional group) and mangosteen and kiwi fruit (exotic fruit), which also contained the highest levels of protocatechuic, p-coumaric, ferulic acids and quercetin. In conclusion, for the first time, the interaction of the polyphenols with human serum albumin was evaluated by fluorometry/FTIR. The obtained binding profiles allowed the comparison of three different groups of fruits. A mixture of these fruits can be recommended for consumption.
Ovarian cancer is characterized by a high rate of recurrence and a poor prognosis. Ferroptosis, a programmed cell death that is dependent on iron and lipid peroxidation, has emerged as a novel therapeutic target in recent years. This study investigated the effects of Obacunone, a naturally occurring compound present in citrus fruits, on the induction of ferroptosis in ovarian cancer via the Akt/p53 signaling pathway.
Ethnopharmacological Relevance: A significant portion of Mahoran people relies on traditional medicine to address their healthcare needs. However, very few studies have been carried out on this subject, and few data are available on the practices, plants used, and ailments most commonly treated by their traditional medicine.
Aim Of The Study: Within this context, the aim of this study was to identify the diseases most commonly treated by traditional Mahoran medicine, as well as the plants most commonly used against these various ailments.
Department of Food Analysis and Environmental Protection, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, Seminaryjna 3, 85-326 Bydgoszcz, Poland.
The possibility of using kitchen electrolyzed water devices (EWDs) for removing residual concentrations of pesticides (malathion, fenitrothion, and p,p'-DDT) from lemon, cucumber, and carrot surfaces was tested. Three commercial devices with different parameters were tested, and their effectiveness was compared with traditional washing methods using water. Based on the results, it was found that by using EWDs, the best removal of water-soluble pesticides was achieved with malathion and fenitrothion (reduction of up to 80%).
LN19183 is a standardized composition of (Christm) Swingle (CA) fruit rind and L. (TC) seed extracts that have recently been demonstrated to increase resting energy expenditure (REE) and reduce body fat in rats. CA and TC are important herbs in traditional medicine for various health benefits.
Taking Citri Reticulatae Pericarpium (CRP) as an example, it is proved that there are differences between the powder decoction and pieces decoction of traditional Chinese medicine (TCM). In this study, an ultra-high performance liquid chromatography quadrupole exactive orbitrap MS/MS (UHPLC-Q-Exactive Orbitrap MS/MS) method was established to characterize 80 chemical components of CRP. The content of components was compared based on extraction rate, alcohol solubility rate, and mass spectrum peak area.
