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Prussian Blue Nanozyme Featuring Enhanced Superoxide Dismutase-like Activity for Myocardial Ischemia Reperfusion Injury Treatment.
ACS Nano
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Jiangsu Key Laboratory for Biomaterials and Devices, School of Biomedical Sciences and Medical Engineering, Southeast University, Nanjing 210096, P. R. China.
The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of the ischemic myocardial area, resulting in secondary damage termed myocardial ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation and inflammatory reactions stand as primary culprits behind MIRI. Current strategies focusing on ROS-scavenging and anti-inflammatory actions have limited remission of MIRI.
View Article and Find Full Text PDFOn the Mechanism of Light-Driven O Evolution by the Mn(III) Complex [Mn(salpd)(OH)] and Quinone.
Inorg Chem
January 2025
Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
In this study, we apply TD-DFT and DFT calculations to explore the mechanistic details of O evolution in an artificial system that closely resembles Photosystem II (PSII). The reaction involves mononuclear Mn(III) complex [Mn(salpd)(OH)] and -benzoquinone under light-driven conditions. Our calculations reveal that the Schiff-base ligand salpd plays a crucial role in several key steps of the reaction, including the light-mediated oxidation of [Mn(salpd)(OH)] to [Mn(salpd)(OH)] by -benzoquinone, the subsequent oxidation of [Mn(salpd)(OH)] to the key Mn(V) intermediate [Mn(salpd)(O)], and the critical O-O bond formation step.
View Article and Find Full Text PDFiTRAQ proteomic analysis of the anterior insula in morphine-induced conditioned place preference rats with high-frequency deep brain stimulation intervention.
Addict Biol
January 2025
Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Morphine dependence or addiction is a serious global public health and social problem, and traditional treatments are very limited. Deep brain stimulation (DBS) has emerged as a new potential treatment for drug addiction. Repeated use of morphine leads to neuroadaptive and molecular changes in the addiction-related brain regions.
View Article and Find Full Text PDFPrevalence of Plasmid-Mediated Fluoroquinolone Resistance Genes in Pseudomonas aeruginosa Among Patients at Aleppo University Hospital, Syria.
J Clin Lab Anal
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Department of Microbiology, Faculty of Sciences, University of Aleppo, Aleppo, Syria.
Background: Pseudomonas aeruginosa is a significant opportunistic pathogen, especially in hospital-acquired infections, with plasmid-mediated fluoroquinolone resistance posing a major healthcare threat. This research aimed to isolate fluoroquinolone-resistant P. aeruginosa from patients at Aleppo University Hospital, assess the prevalence of fluoroquinolone resistance, confirm molecular identity, identify plasmid-associated resistance genes, and investigate virulence factors.
View Article and Find Full Text PDFRadical Brook rearrangement: past, present, and future.
Chem Soc Rev
January 2025
The Institute for Advanced Studies, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University, 299 Bayi Road, Wuhan, 430072, China.
The Brook rearrangement has emerged as one of the most pivotal transformations in organic chemistry, with broad applications spanning organic synthesis, drug design, and materials science. Since its discovery in the 1950s, the anion-mediated Brook rearrangement has been extensively studied, laying the groundwork for the development of numerous innovative reactions. In contrast, the radical Brook rearrangement has garnered comparatively less attention, primarily due to the challenges associated with the controlled generation of alkoxyl radicals under mild conditions.
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