AI Article Synopsis
- - Leptospirosis is a severe disease caused by bacteria, and the authors investigated the immune responses in resistant mice versus susceptible hamsters during early infection.
- - They found that the immune response, specifically the ratio of anti-inflammatory cytokine IL-10 to pro-inflammatory cytokines TNF-α and IL-1β, was higher in mice than in hamsters, indicating that the host's immune response plays a significant role in survival and disease expression.
- - Additionally, using a technique to neutralize IL-10 in infected mice revealed that this cytokine may affect how well the host clears the bacteria and regulates other immune responses.
Article Abstract
Leptospirosis is a severe zoonosis which immunopathogenesis is poorly understood. We evaluated correlation between acute form of the disease and the ratio of the anti-inflammatory cytokine IL-10 to the pro-inflammatory TNF-α and IL-1β expression during the early phase of infection comparing resistant mice and susceptible hamsters infected with two different species of virulent Leptospira. The IL-10/TNF-α and IL-10/IL-1β expression ratios were higher in mouse compared to hamster independently of the Leptospira strain, suggesting a preponderant role of the host response and notably these cytokines in the clinical expression and survival to leptospirosis. Using an IL-10 neutralization strategy in Leptospira-infected mouse model, we also showed evidence of a possible role of this cytokine on host susceptibility, bacterial clearance and on regulation of cytokine gene expression.
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| http://dx.doi.org/10.1016/j.cyto.2017.03.009 | DOI Listing |
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