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Iron in the migraine brain.
Histol Histopathol
December 2024
Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, Türkiye.
Iron, a vital element for numerous peripheral and central nervous system functions, is a key player in DNA synthesis, gene expression, myelination, neurotransmission, and mitochondrial electron transport. Iron has utmost importance in various neurological functions, including neurotransmitter synthesis and brain cell metabolism. Migraine is a neurogliovascular disorder in which neuroinflammation plays a crucial role.
View Article and Find Full Text PDFDifferential diagnosis of iron deficiency anemia from aplastic anemia using machine learning and explainable Artificial Intelligence utilizing blood attributes.
Sci Rep
January 2025
L&T Technology Services Limited, Mysore, Karnataka, India.
As per world health organization, Anemia is a most prevalent blood disorder all over the world. Reduced number of Red Blood Cells or decrease in the number of healthy red blood cells is considered as Anemia. This condition also leads to the decrease in the oxygen carrying capacity of the blood.
View Article and Find Full Text PDFIn defence of ferroptosis.
Signal Transduct Target Ther
January 2025
The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation of ferroptosis is conceived to occur not by an endogenous executioner, but by the withdrawal of cellular guardians that otherwise constantly oppose ferroptosis induction. Here, we profile key ferroptotic defence strategies including iron regulation, phospholipid modulation and enzymes and metabolite systems: glutathione reductase (GR), Ferroptosis suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Dihydrofolate reductase (DHFR), retinal reductases and retinal dehydrogenases (RDH) and thioredoxin reductases (TR).
View Article and Find Full Text PDFAGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury.
Ageing Res Rev
December 2024
Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address:
Traumatic brain injury (TBI) presents significant risks concerning mortality and morbidity. Individuals who suffer from TBI may exhibit mood disorders, including anxiety and depression. Both preclinical and clinical research have established correlations between TBI and disturbances in the metabolism of amino acids, lipids, iron, zinc, and copper, which are implicated in the emergence of mood disorders post-TBI.
View Article and Find Full Text PDFAn assessment of cord ferritin concentration and its predictors among a cohort of Canadian preterm and term infants.
Br J Nutr
January 2025
Food, Nutrition and Health, The University of British Columbia, Vancouver, Canada.
Low iron stores at birth may adversely influence child cognitive and motor development. The aims of this study were to assess cord blood iron levels and explore maternal and neonatal factors associated with iron status. Cord blood specimens (=46) were obtained from the BC Children's Hospital BioBank in Vancouver, Canada.
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