AI Article Synopsis
- DNA methylation is a crucial epigenetic modification governed by DNA methyltransferases, with TET proteins playing a key role in converting 5-methylcytosine to 5-hydroxymethylcytosine, influencing DNA demethylation.
- The paper reviews how TET proteins and changes in DNA modification affect the development and function of T and B cells in both healthy and disease states.
- It also highlights the mechanisms by which TET proteins and 5hmC influence gene expression, chromatin structure, and transcriptional networks, while discussing ongoing research questions in the field.
Article Abstract
DNA methylation is established by DNA methyltransferases and is a key epigenetic mark. Ten-eleven translocation (TET) proteins are enzymes that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidization products (oxi-mCs), which indirectly promote DNA demethylation. Here, we provide an overview of the effect of TET proteins and altered DNA modification status in T and B cell development and function. We summarize current advances in our understanding of the role of TET proteins and 5hmC in T and B cells in both physiological and pathological contexts. We describe how TET proteins and 5hmC regulate DNA modification, chromatin accessibility, gene expression, and transcriptional networks and discuss potential underlying mechanisms and open questions in the field.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374156 | PMC |
| http://dx.doi.org/10.3389/fimmu.2017.00220 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development.
Front Biosci (Landmark Ed)
January 2025
School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, SE5 9NU London, UK.
Cardiovascular disease (CVD) is the most prevalent cause of mortality and morbidity in the Western world. A common underlying hallmark of CVD is the plaque-associated arterial thickening, termed atherosclerosis. Although the molecular mechanisms underlying the aetiology of atherosclerosis remain unknown, it is clear that both its development and progression are associated with significant changes in the pattern of DNA methylation within the vascular cell wall.
View Article and Find Full Text PDFOverexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in species.
mSphere
January 2025
United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto, Kagoshima, Japan.
RNA-binding protein Nrd1 plays a role in RNA polymerase II transcription termination. In this study, we showed that the orthologous NrdA is important in global mRNA expression and secondary metabolism in species. We constructed an conditional expression strain using the Tet-On system in mut.
View Article and Find Full Text PDFTetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
J Pharm Anal
October 2024
Department of Dermatology, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear.
View Article and Find Full Text PDFFirst report of Haemaphysalis bispinosa, molecular-geographic relationships of Ixodes granulatus and a new Dermacentor species from Vietnam.
Parasit Vectors
January 2025
Department of Parasitology, National Institute of Veterinary Research, Hanoi, Vietnam.
Background: Vietnam and its region are regarded as an ixodid tick biodiversity hotspot for at least two genera: Haemaphysalis and Dermacentor. To contribute to our knowledge on the tick fauna of this country, ticks from these two genera as well as an Ixodes species were analyzed morphologically and their molecular-phylogenetic relationships were examined in taxonomic and geographical contexts.
Methods: For this study, seven Haemaphysalis sp.
Genomics yields biological and phenotypic insights into bipolar disorder.
Nature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!