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Polyproline-Polyornithine Diblock Copolymers with Inherent Mitochondria Tropism.
Adv Mater
January 2025
Príncipe Felipe Research Center, Polymer Therapeutics Lab., Valencia, 46012, Spain.
Mitochondria play critical roles in regulating cell fate, with dysfunction correlating with the development of multiple diseases, emphasizing the need for engineered nanomedicines that cross biological barriers. Said nanomedicines often target fluctuating mitochondrial properties and/or present inefficient/insufficient cytosolic delivery (resulting in poor overall activity), while many require complex synthetic procedures involving targeting residues (hindering clinical translation). The synthesis/characterization of polypeptide-based cell penetrating diblock copolymers of poly-L-ornithine (PLO) and polyproline (PLP) (PLO-PLP, n:m ratio 1:3) are described as mitochondria-targeting nanocarriers.
View Article and Find Full Text PDFEvaluation of Colon Capsule Utilisation in Europe-CAPTURE EU Survey Findings.
J Clin Med
December 2024
Institute of Precision Diagnostics & Translational Medicine, University Hospital of Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, UK.
Colon capsule endoscopy (CCE) is a non-invasive method for visualising the colon, but its clinical adoption has been slow. Although the COVID-19 pandemic reignited interest in CCE, its role in conventional gastrointestinal investigations remains unclear, leading to varied practices across Europe. This highlights the need for a comprehensive understanding of diverse approaches to CCE in clinical practice.
View Article and Find Full Text PDFDietary Habits of Pregnant Women in Spain: The Role of Nutrition Education in Midwife Consultations.
Nutrients
December 2024
Área de Nutrición y Bromatología, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.
Correct nutrition during pregnancy is key to guaranteeing success at this stage of a woman's life, and nutritional education is the fundamental tool for achieving this. Studies carried out in different countries indicate that pregnant women do not comply with dietary and nutritional recommendations. Given the lack of evidence available in Spain and the importance of this knowledge to be able to assess the need for nutritional intervention in this group, the aim of this study focused on the current status of the issue in Spain: the quality of the diet of Spanish pregnant women and its conditioning factors.
View Article and Find Full Text PDFThe Theatre Safety Club 2024 took place on 6 November in London and on 26 November in Newcastle. The CPDcertified event aimed to educate and provide insight into safety in the operating theatre, boasting an impressive line-up of speakers and sessions that were well attended. The conference was sponsored by Cardinal Health, a leading healthcare company providing value-based product solutions, with a comprehensive portfolio covering mechanical thromboprophylaxis, nutritional insufficiency solutions, thermometry and surgical gloves.
View Article and Find Full Text PDFThe Omics-Driven Machine Learning Path to Cost-Effective Precision Medicine in Chronic Kidney Disease.
Proteomics
January 2025
School of Public Health, University of Haifa, Haifa, Israel.
Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD. In contrast, omics technologies have shed light on the molecular mechanisms of CKD, helping to identify biomarkers for disease assessment and management.
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