AI Article Synopsis
- The study focuses on oxidation-initiated Nazarov reactions involving 1,4-pentadien-3-yl ethers in the presence of DDQ, a well-known oxidizing agent.
- These reactions lead to the formation of cyclopentanone products that maintain both newly created stereocenters and an exocyclic methylene unit by means of regioselective elimination.
- Additionally, the research introduces a method utilizing catalytic DDQ paired with MnO as the final oxidant to enhance the reaction process.
Article Abstract
Oxidation-initiated Nazarov reactions of 1,4-pentadien-3-yl ethers take place in the presence of DDQ. Termination by regioselective elimination preserves both stereocenters created during electrocyclization, providing cyclopentanone products bearing an exocyclic methylene unit. Use of catalytic DDQ with MnO as terminal oxidant is also described.
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| http://dx.doi.org/10.1002/anie.201701748 | DOI Listing |
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