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Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report.
Front Psychiatry
January 2025
Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Bipolar disorder (BD) is a prevalent mood disorder characterized by alternating episodes of depression and mania, often accompanied by varying degrees of cognitive impairment. Cognitive impairments often serve as indicators of a bleak prognosis or the likelihood of progressing to dementia. Additionally, some studies suggest that individuals diagnosed with BD may undergo a decline in hippocampal volume.
View Article and Find Full Text PDFAcute Vision Loss as the Sole Presenting Symptom of Posterior Reversible Encephalopathy Syndrome.
Cureus
December 2024
Radiology, Second Health Cluster, Jeddah, SAU.
A 45-year-old female with poorly controlled HTN presented with sudden, painless bilateral vision loss over 12 hours. On examination, she had only light perception in both eyes, with normal fundoscopy and no focal neurological deficits. Laboratory tests revealed mildly elevated creatinine and proteinuria.
View Article and Find Full Text PDFMapping Dynamic Protein Clustering with AIEgen-Active Chemigenetic Probe.
Angew Chem Int Ed Engl
January 2025
East China University of Science and Technology, Insitute of Fine Chemicals, Meilong Road 130, Shanghai, China, 200237, Shanghai, CHINA.
Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing crucial roles in cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior and subtle microenvironment variation, present significant hurdles in probe chemistry for tracking protein clustering dynamics. Herein, we report a bilateral-tailored chemigenetic probe, in which an "amphiphilic" AIEgen QMSO3Cl is covalently conjugated to a protein tag that is genetically fused to protein-of-interest (POI).
View Article and Find Full Text PDFSensitivity of Functional Arterial Spin Labelling in Detecting Cerebral Blood Flow Changes.
Br J Hosp Med (Lond)
December 2024
Department of Neurology, Wuhan Brain Hospital, General Hospital of Yangtze River Shipping, Wuhan, Hubei, China.
Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) method. ASL techniques can quantitatively measure cerebral perfusion by fitting a kinetic model to the difference between labelled images (tag images) and ones which are acquired without labelling (control images). ASL functional MRI (fMRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer instead of depending on vascular blood oxygenation level.
View Article and Find Full Text PDFTemporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.
Neuroradiology
January 2025
Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Aims: To test utility of diffusion MRI-derived indices in carotid endarterectomy (CEA), change of diffusion tensor imaging (DTI) metrics, cerebral white matter (WM) volumes were evaluated and predictors of overall mortality determined.
Methods: Prospectively enrolled participants had preoperative, immediate and late postoperative DTI after CEA. WM volumes, DTI metrics (fractional anisotropy, FA; axial, radial, mean diffusivities; AD, RD, MD, respectively) were calculated for the index/contralateral hemispheres at all time points.
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