AI Article Synopsis
- Oxidative stress and inflammation contribute to diabetic nephropathy (DN), and Tanshinone IIA (Tan) is known for its antioxidant and anti-inflammatory effects.
- The study aimed to investigate if Tan could reduce kidney damage in rats with diabetes induced by streptozotocin (STZ) using a daily dose of 10mg/kg over 12 weeks.
- Results showed that Tan treatment reduced albuminuria and improved kidney tissue health, while also decreasing oxidative stress and inflammation, indicating its potential as a treatment for DN.
Article Abstract
Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458258 | PMC |
| http://dx.doi.org/10.18632/oncotarget.16651 | DOI Listing |
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