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Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts.
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Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address:
Neglecting proper skin care and repeated exposure to ultraviolet (UV) radiation can have serious consequences, including skin burns, photoaging and even the development of skin cancer. UV radiation-induced damage is mediated by highly unstable and reactive molecules, named reactive oxygen species (ROS). To counteract ROS, the skin has an endogenous antioxidant system.
View Article and Find Full Text PDFModulation of biological activities in adipose derived stem cells by histone deacetylation.
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The Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Difficult-to-heal wounds management accounts for about 4% of healthcare costs, highlighting the need for innovative solutions. Extracellular signals drive cell proliferation during tissue regeneration, while epigenetic mechanisms regulate stem cell homeostasis, differentiation, and skin repair. Exploring epigenetic regulation in adipose-derived stem cells (ADSCs) holds promise for improving skin injury treatments.
View Article and Find Full Text PDFPhenyl arsine oxide (PAO) is a vesicant, similar to Lewisite, a potential chemical warfare agent and an environmental contaminant. PAO-induced skin burns can trigger acute organ injury, including lungs. We have recently demonstrated that PAO burns can also has a delayed toxicity, although the specific mechanism/s remain to be determined.
View Article and Find Full Text PDFMulti-omics analysis to explore the molecular mechanisms related to keloid.
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Dermatology Hospital, Southern Medical University, Guangzhou, China. Electronic address:
Background: Keloid is a benign skin tumor that result from abnormal wound healing and excessive collagen deposition. The pathogenesis is believed to be linked to genetic predisposition and immune imbalance, although the precise mechanisms remain poorly understood. Current therapeutic approaches may not consistently yield satisfactory outcomes and are often accompanied by potential side effects and risks.
View Article and Find Full Text PDFExperience of multidisciplinary cooperation in treating 15 extensively burned casualties：The Zhejiang LNG tanker explosion on 13 June 2020.
Burns
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Department of Burns and Wound Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou 310009, PR China. Electronic address:
Background: On June 13, 2020, an explosion involving a liquefied natural gas (LNG) tanker truck occurred in eastern China. Fifteen patients with extremely severe burns (referred to as "June 13" patients) were treated in the burn-intensive care unit (ICU) joint ward within the general ICU.
Methods: A multidisciplinary treatment team comprising 129 doctors, 126 nurses, and 165 auxiliary staff members was assembled.
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