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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355362 | PMC |
| http://dx.doi.org/10.18632/oncotarget.15321 | DOI Listing |
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The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation.
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March 2024
PhyMedExp, Univ Montpellier, CNRS, INSERM, Montpellier, France.
Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate the importance of EJC for the correct splicing of the 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involved in cytoskeletal organization and cell signaling.
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