The self-assembling tendencies of guanosine-5'-monophosphate (GMP) can be drastically increased using polyamines, with potential applications in the production of biocompatible smart materials, as well as for the design of antitumor drugs based on G-quadruplex stabilization. Results from scanning electron microscopy (SEM), wide angle X-ray scattering (WAXS), rheology, and nuclear magnetic resonance (NMR) z-spectroscopy studies are presented.
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http://dx.doi.org/10.1002/chem.201700642 | DOI Listing |
Plant Physiol Biochem
November 2023
College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, PR China. Electronic address:
Salt stress adversely affects the growth, development, and yield of tomato (Solanum lycopersicum). SAM Synthetase (SAMS), which is responsible for the biosynthesis of S-adenosylmethionine (SAM, a precursor of polyamine biosynthesis), participates in plant response to abiotic stress. However, the regulatory mechanism of SAMS-mediated salt stress tolerance remains elusive.
View Article and Find Full Text PDFImmunity
November 2023
Department of Pathogenic Biology, Key Laboratory of Infection and Immunity of Shandong Province, and Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. Electronic address:
Cyclic guanosine monophosphate (GMP)-AMP (cGAMP) synthase (cGAS) is a universal double-stranded DNA (dsDNA) sensor that recognizes foreign and self-DNA in the cytoplasm and initiates innate immune responses and has been implicated in various infectious and non-infectious contexts. cGAS binds to the backbone of dsDNA and generates the second messenger, cGAMP, which activates the stimulator of interferon genes (STING). Here, we show that the endogenous polyamines spermine and spermidine attenuated cGAS activity and innate immune responses.
View Article and Find Full Text PDFHepatol Commun
April 2023
Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu City, Japan.
Unlabelled: Background: Various vaccine adjuvants have been developed to eliminate HBV from patients with chronic HBV infection. In addition, spermidine (SPD), a type of polyamine, has been reported to enhance the activity of immune cells. In the present study, we investigated whether the combination of SPD and vaccine adjuvant enhances the HBV antigen-specific immune response to HBV vaccination.
View Article and Find Full Text PDFMolecules
January 2020
Department of Chemistry and Biochemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate and can, in principle, occur in healthy tissue as well as cancerous tissue, potentially leading to side effects in vivo. Here we present pH-dependent intramolecular coordination of an arene-tethered sulfonamide functionality in organometallic ruthenium(II) ethylenediamine complexes as a route to controlling the coordination environment about the central metal atom.
View Article and Find Full Text PDFJ Environ Sci (China)
February 2020
State key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
In this study, we report a novel magnetic biomimetic nanozyme (FeO@Cu/GMP (guanosine 5'-monophosphate)) with high laccase-like activity, which could oxidize toxic o-phenylenediamine (OPD) and remove phenolic compounds. The magnetic laccase-like nanozyme was readily obtained via complexed Cu and GMP that grew on the surface of magnetic FeO nanoparticles. The prepared FeO@Cu/GMP catalyst could be magnetically recycled for at least five cycles while still retaining above 70% activity.
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