Amplification of the candidate oncogene in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for understanding the phenotypes and treat SEC62 tumors, which are characterized by high ER stress tolerance.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383369 | PMC |
| http://dx.doi.org/10.1080/23723556.2016.1264351 | DOI Listing |
Publication Analysis
Top Keywords
role sec62
8
stress tolerance
8
sec62 maintenance
4
maintenance link
4
link stress
4
tolerance sec62-overexpressing
4
sec62-overexpressing tumors?
4
tumors? amplification
4
amplification candidate
4
candidate oncogene
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!