AI Article Synopsis
- Cellular therapies show promise in restoring vision, focusing on embryonic, adult, and induced pluripotent stem cells for regenerative efforts.
- Three main approaches identified include sustained drug delivery, immunomodulation, and differentiation into ocular structures.
- Despite proof-of-concept for stem cell differentiation in lab settings, practical application for vision correction is still developing, with many requirements yet to be clarified.
Article Abstract
The promising role of cellular therapies in the preservation and restoration of visual function has prompted intensive efforts to characterize embryonic, adult, and induced pluripotent stem cells for regenerative purposes. Three main approaches to the use of stem cells have been described: sustained drug delivery, immunomodulation, and differentiation into various ocular structures. Studies of the differentiation capacity of all three types of stem cells into epithelial, neural, glial and vascular phenotypes have reached proof-of-concept in culture, but the correction of vision is still in the early developmental stages, and the requirements for effective implementation are still unclear. We present an overview of some of the preclinical findings on stem-cell rescue and regeneration of the cornea and retina in acute injury and degenerative disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361491 | PMC |
| http://dx.doi.org/10.4103/1673-5374.200793 | DOI Listing |
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