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| http://dx.doi.org/10.3389/fmicb.2017.00506 | DOI Listing |
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cGAS-like receptors drive a systemic STING-dependent host response in Drosophila.
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Sino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. Electronic address:
cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its exact contribution at the organismal level remains uncharacterized. Here, we use STING::GFP knockin reporter Drosophila flies to document activation of the pathway in vivo.
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National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, State Key Laboratory for Complex Severe and Rare Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, 100005, Beijing, China.
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Faculty of Health, School of Biomedical Science, Centre for Immunology and Infection Control, Queensland University of Technology, Brisbane, Queensland 4006, Australia.
With ~78 million cases yearly, the sexually transmitted bacterium Neisseria gonorrhoeae is an urgent threat to global public health due to continued emergence of antimicrobial resistance. In the male reproductive tract, untreated infections may cause permanent damage, poor sperm quality, and subsequently subfertility. Currently, few animal models exist for N.
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Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
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