AI Article Synopsis
- Vitamin D and its metabolites play a vital role in the endocrine system, helping to maintain calcium balance in the body, particularly through the regulation of serum calcium levels.
- The production of the active form of vitamin D, 1,25 dihydroxyvitamin D, is influenced by dietary calcium intake and physiological changes such as growth and aging.
- 1,25(OH) D primarily enhances intestinal calcium absorption during growth, but it also has important functions in the kidneys and bones.
Article Abstract
Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium levels so that they are maintained within a very narrow range. To achieve this goal, regulatory events occur in coordination at multiple tissues, e.g. the intestine, kidney, bone, and parathyroid gland. Production of the vitamin D endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH) D) is regulated by habitual dietary calcium intake and physiologic states like growth, aging, and the menopause. The molecular actions of 1,25(OH) D on calcium regulating target tissues are mediated predominantly by transcription controlled by the vitamin D receptor. A primary role for 1,25(OH) D during growth is to increase intestinal calcium absorption so that sufficient calcium is available for bone mineralization. However, vitamin D also has specific actions on kidney and bone.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529228 | PMC |
| http://dx.doi.org/10.1016/j.mce.2017.04.008 | DOI Listing |
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