AI Article Synopsis
- Researchers found that baseline JAK phosphorylation levels in blood cells can predict how well early rheumatoid arthritis patients respond to synthetic DMARDs.
- The study involved 35 patients and examined JAK phosphorylation in various immune cell types using blood samples and flow cytometry.
- Results showed that high JAK3 levels and low JAK2 levels in specific immune cells were linked to better treatment outcomes, suggesting a potential biomarker for predicting remission.
Article Abstract
Background: We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4 T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the baseline phosphorylation profiles of Janus kinases (JAKs) in blood leukocytes with respect to treatment response in early RA.
Methods: Thirty-five DMARD-naïve patients with early RA provided blood samples for whole blood flow cytometric determination of phosphorylation of JAKs in CD4 and CD8 T cells, CD19 B cells, and CD14 monocytes. Treatment response was determined after 1 year of treatment with synthetic DMARDs, with remission defined as absence of tender and swollen joints and normal erythrocyte sedimentation rate. Exact logistic regression was used to investigate the association of baseline variables with treatment response. Ninety-five percent CIs of means were estimated by bias-corrected bootstrapping.
Results: High JAK3 phosphorylation in CD4 and CD8 T cells, CD19 B cells, and CD14 monocytes and low JAK2 phosphorylation in CD14 monocytes were significantly associated with remission following treatment with synthetic DMARDs.
Conclusions: Baseline JAK phosphorylation profile in peripheral blood leukocytes may provide a means to predict treatment response achieved by synthetic DMARDs among patients with early RA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387378 | PMC |
| http://dx.doi.org/10.1186/s13075-017-1278-0 | DOI Listing |
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