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Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc mice. | LitMetric

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc mice.

Nat Commun

Department of Microbiology and Immunology, Stritch School of Medicine, Health Sciences Division, Loyola University Chicago, Maywood, Illinois 60153, USA.

Published: April 2017

AI Article Synopsis

Article Abstract

Inducing tumour-specific adaptive immunity, such as cytotoxic T lymphocyte (CTL) response, can result in promising antitumour effect against several human malignancies, especially in combination with immune checkpoint blockade strategies. However, little is known whether activation of innate immunity can lead to direct tumoricidal effect. Here, we develop a papilloma pseudovirus-based oral immunotherapeutic approach that shows strong tumoricidal effects in the gut, resulting in an almost tripled lifespan of Apc mice (an animal model of human intestinal tumorigenesis). Mechanistically, these pseudoviruses activate the NLRP3 and AIM2 inflammasomes, leading to caspase-1-mediated tumour regression that is dependent on neither cytotoxic T lymphocytes nor humoral immune response. Blocking caspase-1 activation abrogated the therapeutic effects of the pseudoviruses. Thus, targeting innate immune sensors in tumours by the pseudoviruses might represent a strategy to treat intestinal tumours.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394268PMC
http://dx.doi.org/10.1038/ncomms15004DOI Listing

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