AI Article Synopsis
- Gelatinases belong to the matrix metalloproteinase (MMP) family and are crucial for extracellular matrix (ECM) degradation, impacting chronic kidney disease (CKD) development.
- Their expression and activity are influenced by cell signaling pathways, hypoxia, and changes in cell membrane structure.
- Research is increasingly focused on their non-proteolytic functions and interactions with various factors like TNFs and oxidative stress, enhancing our understanding of their role in CKD.
Article Abstract
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation are closely related to the cell signaling pathways, hypoxia and cell membrane structural change. Gelatinases also can affect the development and progression of CKD through the various interactions with tumor necrosis factors (TNFs), monocyte chemoattractant proteins (MCPs), growth factors (GFs), oxidative stress (OS), and so on. Currently, their non-proteolytic function is a hot topic of research, which may also be associated with the progression of CKD. Therefore, with the in-depth understanding about the function of gelatinases, we can have a more specific and accurate understanding of their role in the human body.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412360 | PMC |
| http://dx.doi.org/10.3390/ijms18040776 | DOI Listing |
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