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The relationship between excessive iodine during pregnancy and adverse pregnancy complications.
Endocrine
December 2024
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Purpose: Iodine nutrition during pregnancy plays an important role in fetal development and maternal outcomes. Iodine deficiency has been proved to be associated with maternal thyroid dysfunction, adverse fetal outcomes and neurodevelopmental disorders in offspring. At present, there are few studies concentrate on the effects of iodine excess during pregnancy on thyroid function, maternal and neonatal outcomes, and the results are still controversial.
View Article and Find Full Text PDFTreatment Versus Observation in Early Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
J Clin Endocrinol Metab
December 2024
Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh.
Purpose: Early gestational diabetes mellitus (eGDM) refers to elevated blood glucose levels not meeting the criteria for overt diabetes before 20 weeks gestation. Observational studies link eGDM to adverse outcomes, but randomized controlled trial (RCT) evidence on early intervention benefits remains inconclusive. To address this, we performed a systematic review and meta-analysis (SRM) of RCTs on this subject.
View Article and Find Full Text PDFIntravenous gene therapy improves lifespan and clinical outcomes in feline Sandhoff Disease.
bioRxiv
November 2024
Scott Ritchey Research Center, Auburn University College of Veterinary Medicine; Auburn, AL, USA.
Sandhoff Disease (SD), a fatal neurodegenerative disorder, is caused by the absence of ß-hexosaminidase (Hex) and subsequent accumulation of GM2 ganglioside in lysosomes. Previous studies have led to adeno-associated virus (AAV) gene therapy for children with GM2 gangliosidosis in both expanded access and Phase I/II clinical trials via intracranial and/or cerebrospinal fluid-based delivery. The current study investigated intravenous (IV) gene therapy of SD cats, treated at one month of age with a bicistronic AAV vector.
View Article and Find Full Text PDFNeuropathic pain - A clinical primer.
Int Rev Neurobiol
November 2024
Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Article Synopsis
- Neuropathic pain is categorized as pain resulting from a lesion or disease in the somatosensory nervous system and can have many different diagnoses.
- A detailed patient history, along with standardized questionnaires and pain drawings, helps identify the type of neuropathic pain and accompanying sensory abnormalities, such as allodynia and hyperalgesia.
- Differential diagnosis is crucial, as neuropathic pain can exist alongside other pain types, and additional diagnostic tests may assist in understanding the underlying issues, though the exact relationship between lesions and pain often requires clinical judgment.
Meningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus.
Neurohospitalist
October 2024
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
We describe the case of a 36-year-old woman with a past medical history of low grade right frontal lobe glioma and focal epilepsy presenting with subacute, progressive, multifocal myoclonus and neck and back pain. Unlike her typical seizures, the myoclonus exhibited a distinct semiology, involving both positive and negative muscle jerks affecting multiple limb muscles while sparing the face. In addition, neurological examination revealed low-amplitude, arrhythmic movements of the hands and fingers, resembling minipolymyoclonus.
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