AI Article Synopsis
Article Abstract
Chiral analysis is of great importance to fundamental and applied research in chemical, biological and pharmaceutical sciences. Due to the superiority of mass spectrometry (MS) over other analytical methods in terms of speed, specificity and sensitivity, chiral analysis by MS has attracted much interest in recent years. Chiral analysis by MS typically involves introduction of a chiral selector to form diastereomers with analyte enantiomers, and comparison of the behaviors of diastereomers in MS. Chiral differentiation can be achieved by comparing the relative abundances of diastereomers, the thermodynamic or kinetic constants of ion-molecule reactions of diastereomers in the gas phase, the dissociation of diastereomers in MS/MS, or the mobility of diastereomers in ion mobility mass spectrometry. In this review, chiral recognition and determination of enantiomeric excess by these chiral MS methods were summarized, and the prospects of chiral analysis by MS were discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aca.2017.03.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two decades of imaging photoelectron circular dichroism: from first principles to future perspectives.
Phys Chem Chem Phys
January 2025
Institute of Photonics & Quantum Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.
There has been a significant recent surge in the number of studies interrogating chiral molecules in the gas phase using photoelectron circular dichroism (PECD) and related techniques. These investigations have revealed new fundamental insights into the structure and dynamics of chiral species and, furthermore, have the potential to revolutionize the field of chiral analysis for more practical and industrial applications. As it has been just over 20 years since the first PECD imaging experiments were demonstrated - and 10 years since the last dedicated general perspective article on the topic - a new overview now seems extremely timely.
View Article and Find Full Text PDFD-Histidine modulated chiral metal-organic frameworks for discriminating 3,4-Dihydroxyphenylalanine enantiomers based on a chemiluminescence quenching mode.
Anal Chim Acta
February 2025
Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Electronic address:
Background: Drug enantiomers often display distinguishable or even opposite pharmacological and toxicologic activities. Therefore it is of great necessity to discriminate enantiomers for guaranteeing safetyness and effectiveness of chiral drugs. Facile chiral discrimination has long been a noticeable challenge because of the minimal differences in physicochemical properties of enantiomers.
View Article and Find Full Text PDFAn ultrasensitive colorimetric/fluorescent/photothermal sensing platform for the detection of D-amino acids based on carbon dots nanozymes with enhanced peroxidase-like activity.
Mikrochim Acta
January 2025
Department of Chemistry, School of Science, Xihua University, Chengdu, 610039, PR China.
Based on the enhanced peroxidase-like activity of carbon dots nanozymes (CDszymes), with a specific oxidation reaction of D-amino acid oxidase catalysing the formation of HO from D-amino acid, an ultrasensitive sensing platform, was constructed for the quantitative detection of D-amino acids in saliva. With the increase of D-amino acids concentration, the blue color of catalytic product gradually deepend, the fluorescence CDszymes gradually quenched, and the temperature gradually increased. Using D-alanine as D-amino acid models, the detection limits of D-alanine in colorimetric/photothermal/fluorescent mode were 0.
View Article and Find Full Text PDFChiral induction at the nanoscale and spin selectivity in electron transmission in chiral methylated BEDT-TTF derivatives.
Nanoscale
January 2025
Department of Engineering "Enzo Ferrari", (DIEF), Univ. of Modena, Via Vivarelli 10, 41125 Modena, Italy.
Great efforts have been made in the last few decades to realize electronic devices based on organic molecules. A possible approach in this field is to exploit the chirality of organic molecules for the development of spintronic devices, an applicative way to implement the chiral-induced spin selectivity (CISS) effect. In this work we exploit enantiopure tetrathiafulvalene (TTF) derivatives as chiral inducers at the nanoscale.
View Article and Find Full Text PDFBackground And Aims: Dengue is a mosquito-borne viral disease that frequently causes seasonal outbreaks in Bangladesh, particularly during the monsoon months from June to September. Recent outbreaks have shown significant shifts in clinical manifestations, including changes in the timeframe and serotype mixing. This study focused on the clinical and hematological profiles of patients during the 2022 outbreak, which was notably severe.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!