A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable (NFPA 1991) suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. Forty human subjects between the ages of 25 and 50 participated in a protocol approved by the local ethical committee. Six different fully encapsulated impermeable HazMat suits were evaluated in three climates: moderate (24°C, 50% RH, 20°C WBGT), warm-wet (32°C, 60% RH, 30°C WBGT), and hot-dry (45°C, 20% RH, 37°C WBGT, 200 W m-2 radiant load) and at three walking speeds: 2.5, 4, and 5.5 km h-1. The medium speed, 4 km h-1, was tested in all three climates and the other two walking speeds were only tested in the moderate climate. Prior to the test a submaximal exercise test in normal clothing was performed to determine a relationship between heart rate and oxygen consumption (pretest). In total, 163 exposures were measured. Tolerance time ranged from as low as 20 min in the hot-dry condition to 60 min (the maximum) in the moderate climate, especially common at the lowest walking speed. Between the six difference suits limited differences were found, a two-layered aluminized suit exhibited significant shorter tolerance times in the moderate climate, but no other major significant differences were found for the other climates or workloads. An important characteristic of the overall dataset is the large variability between the subjects. Although the average responses seem suitable to be predicted, the variability in the warmer strain conditions ranged from 20 min up to 60 min. The work load in these encapsulated impermeable suits was also significantly higher than working in normal clothing and higher than predicted by the Pandolf equation. Heart rate showed a very strong correlation to body core temperature and was in many cases the limiting factor. Setting the heart rate maximum at 80% of predicted individual maximum (age based) would have prevented 95% of the cases with excessive heat strain. Monitoring of heart rate under operational conditions would further allow individually optimize working times and help in preventing exertional heat stroke.
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http://dx.doi.org/10.1093/annweh/wxw019 | DOI Listing |
Materials (Basel)
November 2024
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
Water vapor-impermeable AlON/HfO bilayer films were constructed through a hybrid high-power impulse magnetron sputtering (HiPIMS) and radio-frequency magnetron sputtering process (RFMS), applied as an encapsulation of flexible electronics such as organic photovoltaics. The deposition of monolithic and amorphous AlON films through HiPIMS was investigated by varying the duty cycles from 5% to 20%. At an accelerated test condition, 60 °C, and 90% relative humidity, a 100 nm thick monolithic AlON film prepared using a duty cycle of 20% exhibited a low water vapor transmission rate (WVTR) of 0.
View Article and Find Full Text PDFSmall
December 2024
Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA.
Prebiotically-plausible compartmentalization mechanisms include membrane vesicles formed by amphiphile self-assembly and coacervate droplets formed by liquid-liquid phase separation. Both types of structures form spontaneously and can be related to cellular compartmentalization motifs in today's living cells. As prebiotic compartments, they have complementary capabilities, with coacervates offering excellent solute accumulation and membranes providing superior boundaries.
View Article and Find Full Text PDFSoft Matter
November 2024
Department of Physics, Graduate School of Science, Tohoku University, Japan.
We discovered a cascade vesicle division system driven by osmotic inflation. Binary giant unilamellar vesicles (GUVs) composed of sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and cholesterol (Chol) were subjected to an osmotic pressure difference by encapsulating membrane-impermeable osmolytes (typically sucrose) in an external aqueous solution containing membrane-permeable osmolytes (typically fructose). This simple setup enabled the mother GUVs to repeatedly form small membrane buds and subsequently undergo divisions over several hundred seconds, resulting in the production of approximately 30-300 daughter GUVs from a single mother GUV.
View Article and Find Full Text PDFInt J Nanomedicine
September 2024
Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
Introduction: The tumor microenvironment (TME) of pancreatic cancer is highly immunosuppressive and characterized by a large number of cancer-associated fibroblasts, myeloid-derived suppressor cells, and regulatory T cells. Stimulator of interferon genes (STING) is an endoplasmic reticulum receptor that plays a critical role in immunity. STING agonists have demonstrated the ability to inflame the TME, reduce tumor burden, and confer anti-tumor activity in mouse models.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2024
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Protein therapeutics play a critical role in treating a large variety of diseases, ranging from infections to genetic disorders. However, their delivery to target tissues beyond the liver, such as the lungs, remains a great challenge. Here, we report a universally applicable strategy for lung-targeted protein delivery by engineering ung-Specific upramolecular anoarticles (LSNPs).
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