AI Article Synopsis
- A new method has been created for catalytic asymmetric electrochemical C-H functionalization of simple ketones.
- This approach uses electrochemical oxidation paired with chiral primary amine catalysis, making it metal- and oxidant-free.
- The process produces various C1-alkylated tetrahydroisoquinolines with high yields and excellent enantioselectivities under mild conditions.
Article Abstract
Catalytic asymmetric electrochemical C-H functionalization of simple ketones has been developed. The transformation is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This metal- and oxidant-free method furnishes diverse C1-alkylated tetrahydroisoquinolines in high yields and with excellent enantioselectivities under very mild conditions.
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| http://dx.doi.org/10.1021/acs.orglett.7b00746 | DOI Listing |
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