A new class of chiral 1,2-amino ether ligands, readily accessible from naturally occurring α-amino- or α-hydroxy acids, was found to provide high levels of both conversion and stereocontrol (up to 95:5 er) in intramolecular carbolithiation reactions, outperforming the benchmark ligand (-)-sparteine. The ligand could be used in a substoichiometric amount (0.25 equiv) without significant loss of enantioselectivity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.7b00423 | DOI Listing |
Publication Analysis
Top Keywords
12-amino ether
8
ether ligands
8
intramolecular carbolithiation
8
accessible 12-amino
4
ligands enantioselective
4
enantioselective intramolecular
4
carbolithiation class
4
class chiral
4
chiral 12-amino
4
ligands accessible
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!