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Oestrogen redux: will transdermal delivery rebalance the risk-benefit equation?
BJU Int
May 2017
Eastern Virginia Medical School, Urology of Virginia, Virginia Beach, VA, USA.
Bokhman Redux: Endometrial cancer "types" in the 21st century.
Gynecol Oncol
February 2017
Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, United States.
In 1983 Jan V. Bokhman, M.D.
View Article and Find Full Text PDFHypothesis: Neuroendocrine Mechanisms (Hypothalamus-Growth Hormone-STAT5 Axis) Contribute to Sex Bias in Pulmonary Hypertension.
Mol Med
October 2015
Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.
Pulmonary hypertension (PH) is a disease with high morbidity and mortality. The prevalence of idiopathic pulmonary arterial hypertension (IPAH) and hereditary pulmonary arterial hypertension (HPAH) is approximately two- to four-fold higher in women than in men. Paradoxically, there is an opposite male bias in typical rodent models of PH (chronic hypoxia or monocrotaline); in these models, administration of estrogenic compounds (for example, estradiol-17β [E2]) is protective.
View Article and Find Full Text PDFDexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
Cardiovasc Res
July 2013
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Glasgow University, West Medical Building, Glasgow G12 8QQ, UK.
Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH.
View Article and Find Full Text PDF[Gender-related differences in functional assessment of serotonergic system in healthy young subjects].
Actas Esp Psiquiatr
October 2008
Clínica Psiquiátrica de la Universidad de Chile. Santiago (Chile).
Introduction: Prolactin stimulation test with serotonergic stimulants has been widely used in the study of diverse psychiatric disorders. However, the characterization of this response in normal subjects is still incomplete.
Objective: To compare the response to serotonin stimulation using dexfenfluramine, a specific serotonergic agent, in young healthy men and women, controlling the menstrual cycle.
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