We present a redox-responsive self-assembly based on a unimolecular platform. Three double-headed amphiphilic molecules composed of β-cyclodextrin (β-CD) and ferrocene (Fc) each with an alkyl chain as a linker (βCD-C-Fc, m = 2, 6, and 10) were synthesized, and their self-assembly behaviors were investigated. The molecules self-assembled into polydisperse micelles that transformed into vesicles upon oxidization of the Fc moieties to Fc. 2D H NMR results suggest that although the three molecules formed aggregates with similar morphologies, their molecular configurations were different because of the different lengths of the alkyl chains. When the linker was a C chain, no host-guest complexes were formed, whereas host-guest recognition was detected for linker lengths of C and C. For the oxidized state samples, there were no host-guest interactions for linker lengths of C and C, whereas the alkyl chain was locked in the cavity of β-CD by host-guest inclusion for the molecule with a C linker. Moreover, reversible redox-responsive self-assemblies based on the three β-CD derivatives with a terminal Fc were successfully achieved. Our results enrich the field of β-CD/Fc reversible self-assembly systems, and provide a possible unimolecular host-guest complexation model in host-guest chemistry.
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http://dx.doi.org/10.1039/c7sm00448f | DOI Listing |
Adv Colloid Interface Sci
December 2024
Department of Chemistry and Centre for Advance Study in Chemistry, Panjab University, Chandigarh, India. Electronic address:
Meeting the contemporary demand for the development of functional, biocompatible, and environment friendly self-assembled structures using efficient, cost-effective, and energy-saving methods, the field of colloids has witnessed a surge in interest. Research into cationic and anionic (catanionic) surfactant combinations has gained momentum due to their distinct advantages and synergistic properties in this context. Catanionic self-assemblies have emerged as promising contenders for addressing these requirements.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
School of Chemistry and Chemical Engineering, Hainan University, 58 Renmin Road, Haikou, Hainan Province 570228, China.
In view of the micro/nanostructure tunability of colloid particles, they acted as agrichemical delivery systems. Herein, supra-amphiphilic colloids were fabricated using a host-guest interfacial recognition-architected emulsion template strategy and controlled their agricultural interfacial interactions with the superhydrophobic target surface. Interestingly, the supramolecular interfacial system possessed redox-stimulated molecular reconfigurability by regulating aggregation/disaggregation behaviors.
View Article and Find Full Text PDFAsian J Pharm Sci
August 2024
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Intracellular bacteria can multiply inside host cells and manipulate their biology, and the efficacy of traditional antibiotic drug therapy for intracellular bacteria is limited by inadequate drug accumulation. Fighting against these stealthy bacteria has been a long-standing challenge. Here, a system of stimuli-responsive lactoferrin (Lf) nanoparticles is prepared using protein self-assembly technology to deliver broad-spectrum antibiotic rifampicin (Rif) (Rif@Lf NPs) for enhanced infection therapy through targeted elimination of intracellular bacteria.
View Article and Find Full Text PDFNanoscale
October 2024
School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Kolkata, India 700032.
Herein, we report the synthesis of an alternating copolymer (ACP) with a bio-reducible amphiphilic polydisulfide backbone and highlight the impact of the alternating monomer connectivity on the self-assembly, morphology, chain-exchange dynamics, drug-release kinetics, and enzyme activity inhibition. Condensation polymerization between hydrophobic 1,10-bis(pyridin-2-yldisulfaneyl)decane and hydrophilic 2,3-mercaptosuccinic acid (1.04 : 1.
View Article and Find Full Text PDFAdv Mater
October 2024
School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
Radicals, with their unpaired electrons, exhibit unique chemical and physical properties that have long intrigued chemists. Despite early skepticism about their stability, the discovery of persistent radicals has opened new possibilities for molecular interactions. This review examines the mechanisms and applications of radically driven self-assembly, focusing on key motifs such as naphthalene diimides, tetrathiafulvalenes, and viologens, which serve as models for radical assembly.
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