An asynchronous brain computer interface (A-BCI) determines whether or not a subject is on control state, and produces control commands only in case of subject's being on control state. In this study, we propose a novel P300-based A-BCI algorithm that distinguishes control state and noncontrol state of users. Furthermore, A-BCI algorithm combined with a dynamic stopping function that enables users to select control command independent from a fixed number of intensification sequence. The proposed P300-based A-BCI algorithm uses classification patterns to determine control state and uses optimal operating point of receiver operating characteristics curve for dynamic stopping function. The proposed A-BCI algorithm is also combined with region-based paradigm (RBP) based stimulus interface. The A-BCI algorithm is tested on an internet-based environmental control system. A total of ten nondisabled subjects were participated voluntarily in the experiments. Two-level approach of the RBP-based stimulus interface improves noncontrol state detection accuracy up to 100%. Besides, ratio of incorrect command selection at control state is reduced significantly. At control state, ratio of correct selections, incorrect selections, and missed selections are 93.27%, 1.09%, and 5.63%, respectively. On the other hand, dynamic stopping function enables command selections at least two intensifications. Mean number of intensification sequences to complete the given tasks is 3.15. Thanks to dynamic stopping function, it provides a significant improvement on information transfer rate. The proposed A-BCI algorithm is important in terms of practical BCI systems.
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http://dx.doi.org/10.1109/JBHI.2017.2690801 | DOI Listing |
Expert Opin Drug Deliv
January 2025
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Introduction: Although there are numerous options for epilepsy treatment, its effective control continues unsatisfactory. Thus, search for alternative therapeutic options to improve the efficacy/safety binomial of drugs becomes very attractive to investigate. In this context, intranasal administration of antiseizure drugs formulated on state-of-the-art nanosystems can be a promising strategy.
View Article and Find Full Text PDFJAMA
January 2025
Assistant Secretary for Technology Policy/Office of the National Coordinator for Health IT, Washington, DC.
Importance: Health information technology, such as electronic health records (EHRs), has been widely adopted, yet accessing and exchanging data in the fragmented US health care system remains challenging. To unlock the potential of EHR data to improve patient health, public health, and health care, it is essential to streamline the exchange of health data. As leaders across the US Department of Health and Human Services (DHHS), we describe how DHHS has implemented fundamental building blocks to achieve this vision.
View Article and Find Full Text PDFClin Rheumatol
January 2025
Department of Rheumatology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Introduction/objectives: Sjogren's syndrome (SS) is a chronic inflammatory and difficult-to-treat autoimmune disease. Timosaponin AIII (TAIII), a plant-derived steroidal saponin, effectively inhibits cell proliferation, induces apoptosis, and exhibits anti-inflammatory properties. This study explored the mechanisms of action of TAIII in SS treatment by studying gut microbiota and short-chain fatty acids (SCFAs) using fecal metabolomics.
View Article and Find Full Text PDFVet Res Commun
January 2025
Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
Southern right whales (Eubalaena australis) are mysticete cetaceans commonly observed in the coastal waters of Brazil, particularly in Santa Catarina State. There is limited understanding of the causes of calf mortality in this species, particularly concerning infectious diseases. We report a case of omphalophlebitis caused by Streptococcus equi subsp.
View Article and Find Full Text PDFCell Mol Life Sci
January 2025
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Unitat de Farmacologia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain.
Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers' against decapentaplegic homolog (SMAD) complex to its DNA-binding elements. However, the stimuli that control this process are unknown. Here, we examined whether saturated fatty acids (FA), particularly palmitate, regulate nuclear GDF15 levels and the activation of the SMAD3 pathway in human skeletal myotubes and mouse skeletal muscle, where most insulin-stimulated glucose use occurs in the whole organism.
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