This study investigated the toxicity of rats exposed to lead acetate (AcPb) during the second phase of brain development (8-12 days postnatal) in hematological and cerebral parameters. Moreover, the preventive effect of zinc chloride (ZnCl) and N-acetylcysteine (NAC) was investigated. Pups were injected subcutaneously with saline (0.9% NaCl solution), ZnCl (27 mg/kg/day), NAC (5 mg/kg/day) or ZnCl plus NAC for 5 days (3rd-7th postnatal days), and with saline (0.9% NaCl solution) or AcPb (7 mg/kg/day) in the five subsequent days (8th-12th postnatal days). Animals were sacrificed 21 days after the last AcPb exposure. Pups exposed to AcPb presented inhibition of blood porphobilinogen-synthase (PBG-synthase) activity without changes in hemoglobin content. ZnCl pre-exposure partially prevented PBG-synthase inhibition. Regarding neurotoxicity biomarkers, animals exposed to AcPb presented a decrease in cerebrum acetylcholinesterase (AChE) activity and an increase in Pb accumulation in blood and cerebrum. These changes were prevented by pre-treatment with ZnCl, NAC, and ZnCl plus NAC. AcPb exposure caused no alteration in behavioral tasks. In short, results show that AcPb inhibited the activity of two important enzymatic biomarkers up to 21 days after the end of the exposure. Moreover, ZnCl and NAC prevented the alterations induced by AcPb.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12011-017-1009-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tailoring tea residue-derived nitrogen-doped activated carbon for CO adsorption: influence of activation temperature and activating agents.
Environ Sci Pollut Res Int
October 2024
Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), Johor Bahru, 81310 UTM, Johor, Malaysia.
Article Synopsis
- Using new technologies to capture carbon dioxide (CO) is super important for keeping our planet healthy and making a sustainable future.
- This study looked at how changing certain materials, like using tea waste and ammonia, can make better carbon-capturing materials called adsorbents.
- The best results came from using a specific method with sodium hydroxide that made these materials really effective at capturing CO, showing it could hold much more carbon than other types.
Characterization and Ofloxacin Adsorption Studies of Chemically Modified Activated Carbon from Cassava Stem.
Materials (Basel)
July 2022
Faculty of Forestry, Karadeniz Technical University, Trabzon 61080, Turkey.
Cassava is a type of crop popular in Asian countries. It can be easily cultivated and grows to a mature plant in 9 months. Considering its availability, this work studied activated carbon based on cassava stem.
View Article and Find Full Text PDFInhibitory effects of zinc chloride (ZnCl), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on Cd-induced abnormal cell morphology and membrane permeability.
Sci Total Environ
August 2022
Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry and Biology, Faculty of Environment and Life Sciences, Beijing University of Technology, Beijing 100124, PR China.
Cadmium (Cd) could reduce abnormal cell morphology and membrane permeability, however, there are few studies on the detoxification of Cd-reduced cell membrane toxicity. In the present study, we firstly studied the effects of zinc chloride (ZnCl), n-acetyl-L-cysteine (NAC), and calcium/calmodulin dependent protein kinase II inhibitor (KN93) on cell membrane permeability, respectively; then, we studied the inhibitory effects of ZnCl, NAC, and KN93 on Cd-induced abnormal cell membrane permeability by scanning electrochemical microscopy (SECM) scanning imaging, transverse scanning curve and DPV technology. Our results showed that 10 μmol·L ZnCl, 0.
View Article and Find Full Text PDFZinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism.
Am J Physiol Cell Physiol
June 2021
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Leucine-rich repeat-containing 8 (LRRC8) volume-regulated anion channels (VRACs) play important physiological roles in diverse cell types and may represent therapeutic targets for various diseases. To date, however, the pharmacological tools for evaluating the druggability of VRACs have been limited to inhibitors, as no activators of the channel have been reported. We therefore performed a fluorescence-based high-throughput screening (HTS) of 1,184 Food and Drug Administration-approved drugs for compounds that increase VRAC activity.
View Article and Find Full Text PDFToxicity mitigation by N-acetylcysteine and synergistic toxic effect of nano and bulk ZnO to Panagrellus redivivus.
Environ Sci Pollut Res Int
July 2021
Department of Zoology and Animal Ecology, Szent István University, Gödöllő, Hungary.
To better understand the nanosize-relevant toxic effects and underlying mechanisms, N-acetylcysteine (NAC), as a mitigation agent, an ionic form of Zn (ZnCl), and the binary mixture of ZnO with different particle sizes (15 nm and 140 nm), was used in toxicity assays with the nematode Panagrellus redivivus. The ZnCl concentrations were applied to show the amount of dissolved Zn ions present in the test system. Reactive oxygen species (ROS) measuring method was developed to fit the used test system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!