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The Potential Functions of Small Heat Shock Proteins in the Uterine Musculature during Pregnancy. | LitMetric

The Potential Functions of Small Heat Shock Proteins in the Uterine Musculature during Pregnancy.

Adv Anat Embryol Cell Biol

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Dr., University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.

Published: September 2017

AI Article Synopsis

Article Abstract

The small heat shock protein B (HSPB) family is comprised of eleven members with many being induced by physiological stressors. In addition to being molecular chaperones, it is clear these proteins also play important roles in cell death regulation, cytoskeletal rearrangements, and immune system activation. These processes are important for the uterine smooth muscle or myometrium during pregnancy as it changes from a quiescent tissue, during the majority of pregnancy, to a powerful and contractile tissue at labor. The initiation and progression of labor within the myometrium also appears to require an inflammatory response as it is infiltrated by immune cells and it produces pro-inflammatory mediators. This chapter summarizes current knowledge on the expression of HSPB family members in the myometrium during pregnancy and speculates on the possible roles of these proteins during myometrial programming and transformation of the myometrium into a possible immune regulatory tissue.

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Source
http://dx.doi.org/10.1007/978-3-319-51409-3_5DOI Listing

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