AI Article Synopsis
- Circulating bilirubin, a natural antioxidant, is thought to lower stroke risk, but its relationship with stroke remains unclear.
- The study analyzed genetic data from a cohort of Koreans to explore whether serum bilirubin levels causally affect stroke risk using Mendelian randomization.
- Results showed that while higher bilirubin levels were linked to lower stroke risk, the analysis found no causal relationship, suggesting bilirubin is not a determinant of stroke risk in this population.*
Article Abstract
Background And Purpose: Circulating bilirubin, a natural antioxidant, is associated with decreased risk of stroke. However, the nature of the relationship between the two remains unknown. We used a Mendelian randomization analysis to assess the causal effect of serum bilirubin on stroke risk in Koreans.
Methods: The 14 single-nucleotide polymorphisms (SNPs) (<10) including rs6742078 of uridine diphosphoglucuronyl-transferase were selected from genome-wide association study of bilirubin level in the KCPS-II (Korean Cancer Prevention Study-II) Biobank subcohort consisting of 4793 healthy Korean and 806 stroke cases. Weighted genetic risk score was calculated using 14 SNPs selected from the top SNPs.
Results: Both rs6742078 (F statistics=138) and weighted genetic risk score with 14 SNPs (F statistics=187) were strongly associated with bilirubin levels. Simultaneously, serum bilirubin level was associated with decreased risk of stroke in an ordinary least-squares analysis. However, in 2-stage least-squares Mendelian randomization analysis, no causal relationship between serum bilirubin and stroke risk was found.
Conclusions: There is no evidence that bilirubin level is causally associated with risk of stroke in Koreans. Therefore, bilirubin level is not a risk determinant of stroke.
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| http://dx.doi.org/10.1161/STROKEAHA.116.015083 | DOI Listing |
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