The aim of this study was to select developmentally valid and reliable items for inclusion in criterion-referenced (pass > 90%) posttraumatic amnesia (PTA) scale for children aged 4 to 7 years in a prospective cohort study. Fifty-two typically developing children (26 male/26 female) aged 4 to 7 years were administered a set of 10 items (5 orientation, 5 memory) over 3-4 days. The total score obtained on the set of 10 items had poor developmental validity and test-retest reliability. Nevertheless, individual item analysis identified five items (three orientation and two memory items) that were consistently passed by >90% of the children on each day of testing. For these five items the total scores did not differ significantly either between age groups or between days of testing. Test-retest was extremely high (close to 1). The five items had excellent developmental validity and test-retest reliability. This study identified 5 (3 orientation and 2 memory) items that met our selection criterion and form a new PTA scale, the Sydney PTA scale (SYPTAS), for children aged 4 to 7 years.
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http://dx.doi.org/10.1080/21622965.2017.1306443 | DOI Listing |
Bioprocess Biosyst Eng
January 2025
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.
p-Coumaric acid (p-CA), an invaluable phytochemical, has novel bioactivities, including antiproliferative, anxiolytic, and neuroprotective effects, and is the main precursor of various flavonoids, such as caffeic acid, naringenin, and resveratrol. Herein, we report the engineering of Escherichia coli for de novo production of p-CA via the PAL-C4H pathway. As the base strain, we used the E.
View Article and Find Full Text PDFBiotechnol Biofuels Bioprod
January 2025
Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Background: The climate crisis and depleting fossil fuel reserves have led to a drive for 'green' alternatives to the way we manufacture chemicals, and the formation of a bioeconomy that reduces our reliance on petrochemical-based feedstocks. Advances in Synthetic biology have provided the opportunity to engineer micro-organisms to produce compounds from renewable feedstocks, which could play a role in replacing traditional, petrochemical based, manufacturing routes. However, there are few examples of bio-manufactured products achieving commercialisation.
View Article and Find Full Text PDFTransl Stroke Res
January 2025
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4 Ring West Road, Beijing, 100070, Fengtai District, China.
Microcirculatory dysfunction is an important pathophysiology mechanism of early brain injury after aneurysmal subarachnoid hemorrhage (aSAH), which contributes to poor outcomes. The study was performed in Beijing Tiantan Hospital from October 2020 to July 2023. Patients with aSAH who underwent computed tomographic perfusion (CTP) within 24 h after ictus were enrolled prospectively.
View Article and Find Full Text PDFInorg Chem
January 2025
Textile Pollution Controlling Engineering Center of Ministry of Ecology and Environment, College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China.
Carbon capture and storage (CCS) from dilute sources is an important strategy for stabilizing the concentration of atmospheric carbon dioxide and global temperature. However, the adsorption process is extremely challenging due to the sluggish diffusion rate of dilute CO. Herein, -phthalic acid (PTA)-derived hierarchical porous activated carbon (PTA-C) with abundant micro- and mesopores was successfully prepared for dilute CO (2 vol %) capture at ambient conditions.
View Article and Find Full Text PDFLaryngoscope
December 2024
Division of Surgery, University of Western Australia, Perth, Western Australia, Australia.
Objective: To determine which ear environment risk factors impact ossiculoplasty hearing outcomes and to generate a statistically-valid grading system for ossiculoplasty outcome reporting.
Study Type: Retrospective case series.
Methods: A multi-institutional database was generated from cases performed between 2011 and 2019.
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