AI Article Synopsis
- International guidelines for asthma management face challenges in clinical practice due to knowledge gaps and compliance issues, especially in younger patients.
- A new approach called Single Inhaler Therapy (SIT) or Symbicort Maintenance and Reliever Therapy (SMART) has shown safety and efficacy in adults and is being tested in children and adolescents.
- Clinical cases from a clinic indicate positive responses in some children using the SIT regimen, suggesting it may help with compliance, but further studies are necessary to confirm its effectiveness and safety for this age group.
Article Abstract
International guidelines have been edited to standardize asthma management. These guidelines are often difficult to translate to clinical practice because of gaps in the knowledge of clinical practitioners but also because of compliance issues, particularly in children and adolescents. A new approach named SIT (for Single Inhaler Therapy) or SMART (for Symbicort Maintenance and Reliever Therapy) has demonstrated its safety and efficacy in numerous studies of adults with asthma summarized in two Cochrane reviews. We present here three clinical cases from our clinic where this approach was applied to children and adolescents with a clear clinical and functional response for two of them. We suggest that the SIT regimen can be used in some children and adolescents with asthma and has the potential to reduce compliance issues. Moreover asthma phenotypes have been described and it is possible that only some of these phenotypes respond to this regimen. However to confirm the efficacy and safety of the SIT regimen in children and adolescents more studies are needed.
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