In recent years it turned out that there is not only extensive communication between the nucleus and mitochondria but also between mitochondria and lipid droplets (LDs) as well. We were able to demonstrate that a number of proteins shuttle between LDs and mitochondria and it depends on the metabolic state of the cell on which organelle these proteins are predominantly localized. Responsible for the localization of the particular proteins is a protein domain consisting of two -helices, which we termed V-domain according to the predicted structure. So far we have detected this domain in the following proteins: mammalian BAX, BCL-XL, TCTP and yeast Mmi1p and Erg6p. According to our experiments there are two functions of this domain: (1) shuttling of proteins to mitochondria in times of stress and apoptosis; (2) clearing the outer mitochondrial membrane from pro- as well as anti-apoptotic proteins by moving them to LDs after the stress ceases. In this way the LDs are used by the cell to modulate stress response.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357670 | PMC |
| http://dx.doi.org/10.1038/cddiscovery.2017.16 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two-dimensional anion-rich NaCl crystal under ambient conditions.
Nat Commun
January 2025
School of Physical Science and Technology, Ningbo University, Ningbo, China.
The two-dimensional (2D) "sandwich" structure composed of a cation plane located between two anion planes, such as anion-rich CrI, VS, VSe, and MnSe, possesses exotic magnetic and electronic structural properties and is expected to be a typical base for next-generation microelectronic, magnetic, and spintronic devices. However, only a few 2D anion-rich "sandwich" materials have been experimentally discovered and fabricated, as they are vastly limited by their conventional stoichiometric ratios and structural stability under ambient conditions. Here, we report a 2D anion-rich NaCl crystal with sandwiched structure confined within graphene oxide membranes with positive surface potential.
View Article and Find Full Text PDFImaging Characteristics of Primary Mucinous Cystadenocarcinoma of the Breast: A Case Report and Literature Review.
Curr Med Imaging
January 2025
Department of Pathology, Affiliated Jinhua Hospital Zhejiang University School of Medicine, Jinhua, Zhejiang, 32100, P. R. China.
Introduction: Mucinous Cystadenocarcinoma (MCA) of the breast remains a relatively rare condition, and to date, there is no systematic summary of its imaging manifestations. Therefore, this report presents a detailed account of the diagnosis and treatment of mucinous cystadenocarcinoma in a 40-year-old woman, with a particular focus on imaging findings. Additionally, we conducted a comprehensive literature review on this disease and summarized its key imaging features.
View Article and Find Full Text PDFSon of a beach: Coastal development and the loss of natural beaches over time (1919 to 2018) on Okinawa Island, southern Japan.
Mar Pollut Bull
January 2025
Molecular Invertebrate Systematics and Ecology Laboratory, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan; Tropical Biosphere Research Center, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan. Electronic address:
The coastline of Okinawa Island, Japan, has been affected by human-made alterations for decades, often from land reclamation and coastal defense construction. Here, we use an Imperial Japanese Army map made between 1919 and 1921 to describe the composition of the Okinawan coastline approximately 100 years ago, and by overlapping this old map with a modern-day map of Okinawa (2018), we identified 131 sites where coastlines showed clear human-made alterations. For these sites, we examined what kinds of ecosystems were lost and what has replaced them.
View Article and Find Full Text PDFFunctionalized Microsphere Platform Combining Nutrient Restriction and Combination Therapy to Combat Bacterial Infections.
ACS Appl Mater Interfaces
January 2025
Animal-Derived Food Safety Innovation Team, College of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
The escalating prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a critical global health crisis, undermining the efficacy of conventional antibiotic therapies. This pressing challenge necessitates the development of innovative strategies to combat MDR pathogens. Advances in multifunctional drug delivery systems offer promising solutions to reduce or eradicate MDR bacteria.
View Article and Find Full Text PDFA rare case of hydatid cyst presenting as a breast cancer. A case report.
Int J Surg Case Rep
December 2024
Debre Markos University, Surgery Department, Ethiopia. Electronic address:
Article Synopsis
- Hydatid disease, caused by the Echinococcus parasite, is a serious health issue in endemic areas, and breast involvement is notably rare; this case involves a 34-year-old Ethiopian woman initially misdiagnosed with breast cancer.
- The patient presented with a painless swelling in her left breast that persisted for nine months, without symptoms typically associated with cancer, such as discharge or skin changes.
- Diagnostic imaging and tests ultimately confirmed that the mass was a hydatid cyst, highlighting the need for healthcare professionals to consider less common conditions in their diagnosis of breast masses in endemic regions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!