AI Article Synopsis
- Colorectal cancer (CRC) is a major global health issue, and research indicates that plants from the Loranthaceae family possess strong anti-cancer properties.
- The study evaluated the effects of the plant Elytranthe parasitica on colorectal cancer by testing its extracts on human cancer cells and analyzing the bioactive compounds present.
- Results showed that specific fractions of the plant extract inhibited cancer cell growth and induced cell death, with pinocembrin being identified as a key phytochemical that may contribute to its anti-cancer effects, suggesting potential for future natural treatment development.
Article Abstract
Background: Colorectal cancer (CRC) is a highly predominant malignancy affecting millions worldwide. Plants belonging to Loranthaceae family have remarkable chemopreventive properties.
Objective: The goal of the present study was to assess the antiproliferative and apoptosis-inducing effects of stem parts of Elytranthe parasitica (L.) Danser (EP) on colorectal cancer and identify the bioactive phytochemicals.
Material And Methods: EP methanol extract (EP.M) and its subsequent fractions were screened for antiproliferative activity in human colorectal carcinoma HCT 116 cell line. Phytocomposition of the bioactive fraction was analyzed by GC-MS. Further, apoptotic induction and cell cycle arrest was assessed in the most bioactive fractions.
Results: EP.DEE (Diethyl Ether) fraction and a subsequent fraction derived by column chromatography, Fraction 3A (FR 3A) significantly inhibited the proliferation of HCT 116 cells (P < 0.05). FR 3A triggered apoptosis and notably modulated the cell cycle checkpoints. GC-MS analysis of FR 3A revealed the presence of 24 phytochemicals, the most prominent of which was pinocembrin (70.67%), a flavonoid.
Conclusion: Hence, it could be speculated that pinocembrin and its related derivatives may be the chief phytochemicals involved in apoptosis - mediated cytotoxicity of the enriched fraction. Our findings indicate the enriched fraction is a promising candidate which could be developed into a natural chemotherapeutic product for colorectal cancer therapy.
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| http://dx.doi.org/10.1016/j.jiac.2017.02.009 | DOI Listing |
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