AI Article Synopsis
- - The study investigates the use of Ki-67, a marker for tumor growth, in evaluating Surface Epithelial Ovarian Carcinoma (SEOC) to find correlations with tumor grade, stage, and CA125 levels for better diagnosis and prognosis.
- - Conducted at JSS Medical College in Mysuru, the research included 40 SEOC cases, analyzing Ki-67 expression using immunohistochemical methods, revealing that higher Ki-67 levels were linked to poor tumor grade and advanced disease stage.
- - Results indicated that Ki-67 is a cost-effective tool that, when combined with histological data, can assist in determining subtype differentiation, prognosis, the need for chemotherapy, and overall survival predictions for SEOC patients
Article Abstract
Introduction: The Surface Epithelial Ovarian Carcinoma (SEOC) at the moment of diagnosis, the disease is extended beyond the structures of the pelvis. Ki-67 is one of the prognostic marker which determines the growth fraction of a tumour and its over expression is associated with malignancy, tumour aggression, reserved prognosis and metastasis.
Aim: To evaluate the proliferative activity using Ki-67 immuno-staining in SEOC and to correlate with histological subtype, grade, Federation of Gynecology and Obstetrics (FIGO) stage, CA125 levels for diagnostic and prognostic purpose.
Materials And Methods: The study was conducted in JSS Medical College and Hospital, JSS University, Mysuru. It was a descriptive cross-sectional study involving 40 cases of SEOC over a period of two years. The proliferation expression related to Ki-67 antigen was evaluated by immunohistochemical monoclonal MIB-1 antibody. In each case, the Ki-67 labeling index (Ki-67 LI) was articulated as percentage of positively stained cells using high power objective of the microscope (x400).
Results: Among the 40 carcinomas, 26 were serous, five mucinous, four each of clear cell and undifferentiated and one transitional cell carcinoma. A total of 75% were high grade tumours. High Ki-67 LI was associated with high grade tumours (69.9%), high grade serous tumours (65.34%) and advanced FIGO staging (70.6%) with the p-value of <0.001. CA 125 levels did not have a significant correlation with Ki-67 LI.
Conclusion: Ki-67 is an exceptionally a cost effective marker to determine the growth fraction of a tumour cell population. In SEOC histological grade and FIGO stage when combined with Ki-67 LI in histopathology report would help in diagnostic differentiation of subtypes, prognostication, deciding the need for adjuvant chemotherapy and in predicting survival analysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376861 | PMC |
| http://dx.doi.org/10.7860/JCDR/2017/24350.9381 | DOI Listing |
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