Diffuse optical spectroscopy (DOS) and imaging methods have been widely applied to noninvasive detection of brain activity. We have designed and implemented a low cost, portable, real-time one-channel time-resolved DOS system for neuroscience studies. Phantom experiments were carried out to test the performance of the system. We further conducted preliminary human experiments and demonstrated that enhanced sensitivity in detecting neural activity in the cortex could be achieved by the use of late arriving photons.
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http://dx.doi.org/10.1117/1.JBO.22.4.045005 | DOI Listing |
Transl Vis Sci Technol
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: The purpose of this study was to characterize whether pulsed ultrasound (PUS) affects transscleral drug delivery.
Methods: Fluorescein sodium (NaF, 376 Da) and fluorescein isothiocyanate-conjugated dextran 40 (FD-40, 40 kDa) were used as model drugs. Human sclera grafts were placed in modified Franz diffusion cells and were treated by PUS (1 megahertz [MHz], 0.
J Neuroimaging
January 2025
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Background And Purpose: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of white matter damage, which may be related to small vessel disease. This study aimed to investigate the presence of white matter damage in patients with isolated rapid eye movement sleep behavior disorder (RBD) using PSMD.
Methods: We enrolled patients with newly diagnosed isolated RBD confirmed by polysomnography and age- and sex-matched healthy controls.
Background: Emerging research, underscored by the UK National Institute of Health and Care Excellence and the US National Institutes of Health, suggests that age-related hearing loss (ARHL) is linked to the development of dementias such as Alzheimer's disease (AD). In this study, we aim to investigate the neural correlates of ARHL and cognitive impairments based on the changes in white matter (WM) microstructures in a population of non-demented adults.
Method: 129 participants (94 female) aged between 20-79 years old (Mean = 51.
Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild-type mice five days post-injury.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Potassium metal batteries are emerging as a promising high-energy density storage solution, valued for their cost-effectiveness and low electrochemical potential. However, understanding the role of potassiphilic sites in nucleation and growth remains challenging. This study introduces a single-atom iron, coordinated by nitrogen atoms in a 3D hierarchical porous carbon fiber (Fe─N-PCF), which enhances ion and electron transport, improves nucleation and diffusion kinetics, and reduces energy barriers for potassium deposition.
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