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Alternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations.
J Pathol
January 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
DICER1-associated sarcoma is an emerging entity, defined by either somatic or germline dicer 1, ribonuclease III (DICER1) mutations and sharing characteristic morphologic features irrespective of the site of origin. In addition to the DICER1 driver mutation, concurrent genomic alterations, including tumor protein 53 (TP53) inactivation and RAS pathway activation, are frequently detected. Tumors that morphologically resemble malignant peripheral nerve sheath tumor (MPNST) have rarely been reported among DICER1 sarcomas and often pose diagnostic challenges.
View Article and Find Full Text PDFM2 Macrophage Exosomes Reverse Cardiac Functional Decline in Mice with Diet-Induced Myocardial Infarction by Suppressing Type 1 Interferon Signaling in Myeloid Cells.
bioRxiv
September 2024
Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA.
Article Synopsis
- Current heart failure treatments following myocardial infarction (MI) are insufficient, highlighting a gap in cardiovascular care.
- This study explores exosomes from human macrophages treated with the cytokine IL-4 (THP1-IL4-exo), which help improve heart function in mice with MI due to diet-induced coronary artery disease.
- THP1-IL4-exo works by reprogramming specific immune cells and reducing inflammation, ultimately preventing heart damage and preserving heart function after an MI.*
Sucrose-induced metabolic syndrome differentially affects energy metabolism and fiber phenotype of EDL and soleus muscles during exercise in the rat.
Physiol Rep
July 2024
Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Ciudad de México, Mexico.
Molecular mechanisms associated to improvement of metabolic syndrome (MetS) during exercise are not fully elucidated. MetS was induced in 250 g male Wistar rats by 30% sucrose in drinking water. Control rats receiving tap water were controls, both groups received solid standard diet.
View Article and Find Full Text PDFAzole resistance in the pathogenic yeast is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc cluster-containing transcription factor Pdr1. These mutations typically lead to this factor driving high, constitutive expression of target genes like the ATP-binding cassette transporter-encoding gene .
View Article and Find Full Text PDFAzolla filiculoides extract improved salt tolerance in wheat (Triticum aestivum L.) is associated with prompting osmostasis, antioxidant potential and stress-interrelated genes.
Sci Rep
May 2024
Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
The growth and productivity of crop plants are negatively affected by salinity-induced ionic and oxidative stresses. This study aimed to provide insight into the interaction of NaCl-induced salinity with Azolla aqueous extract (AAE) regarding growth, antioxidant balance, and stress-responsive genes expression in wheat seedlings. In a pot experiment, wheat kernels were primed for 21 h with either deionized water or 0.
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