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Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing. | LitMetric

Identification of Virulent Capnocytophaga canimorsus Isolates by Capsular Typing.

J Clin Microbiol

Unité de Recherche en Biologie des Microorganismes, Université de Namur, Namur, Belgium

Published: June 2017

is a dog oral commensal that causes rare but severe infections in humans. was recently shown to be endowed with a capsular polysaccharide implicated in resistance to the innate immune system of the host. Here, we developed the first capsular serotyping scheme. We describe nine different serovars (A to I), and this serotyping scheme allowed typing of 25/25 isolates from human infections but only 18/52 isolates from dog mouths, indicating that the repertoire of capsules in the species is vast. However, while only three serovars (A, B, and C) covered 88% of the human isolates tested (22/25), they covered only 7.7% of the dog isolates (4/52). Serovars A, B, and C were found 22.9-, 14.6-, and 4.2-fold more often, respectively, among human isolates than among dog isolates, with no geographical bias, implying that isolates endowed with these three capsular types are more virulent for humans than other isolates. Capsular serotyping would thus allow identification of virulent isolates in dogs, which could contribute to the prevention of these infections. To this end, we developed a PCR typing method based on the amplification of specific capsular genes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442547PMC
http://dx.doi.org/10.1128/JCM.00249-17DOI Listing

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