This work presents a monolithic laterally-coupled wide-spectrum (350 nm < λ < 1270 nm) optical link in a silicon-on-insulator CMOS technology. The link consists of a silicon (Si) light-emitting diode (LED) as the optical source and a Si photodiode (PD) as the detector; both realized by vertical abrupt np junctions, separated by a shallow trench isolation composed of silicon dioxide. Medium trench isolation around the devices along with the buried oxide layer provides galvanic isolation. Optical coupling in both avalanche-mode and forward-mode operation of the LED are analyzed for various designs and bias conditions. From both DC and pulsed transient measurements, it is further shown that heating in the avalanche-mode LED leads to a slow thermal coupling to the PD with time constants in the ms range. An integrated heat sink in the same technology leads to a ∼ 6 times reduction in the change in PD junction temperature per unit electrical power dissipated in the avalanche-mode LED. The analysis paves way for wide-spectrum optical links integrated in smart power technologies.
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http://dx.doi.org/10.1364/OE.25.005440 | DOI Listing |
We present a novel, to the best of our knowledge, fiber-optic radio frequency (RF) phase synchronization scheme utilizing frequency division multiplexing, eliminating the need for a time reference. The method begins by generating two homologous RF signals with an integer multiple frequency relationship. These signals are then modulated onto the same laser carrier through intensity modulation.
View Article and Find Full Text PDFA polarization-switching pulse interleaver is shown to be effective in reducing timing noise due to polarization mode dispersion in time and frequency transfer based on mode-locked lasers and standard single-mode (SM) fibers. In closed-loop time transfer over a 30-km dispersion-compensated fiber link with 300 fs of differential group delay, polarization interleaving reduced the delay variations to <20 fs. The results indicate that the remaining drift is caused by polarization-dependent loss and by AM-to-PM noise conversion in the photodiodes, suggesting the need for a "double-balanced" phase detector in the receiver, i.
View Article and Find Full Text PDFJ Bacteriol
March 2025
Research Unit in Microorganisms Biology (URBM), Department of Biology, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium.
Copper (Cu) is potentially threatening for living organisms owing to its toxicity at high concentrations, requiring the onset of diverse detoxification strategies to maintain fitness. We previously showed that the environmental conditions modulate the response of the oligotrophic alphaproteobacterium to Cu excess. In the present study, we investigated the role of the Fe-importing TonB-dependent receptor (TBDR) CciT and its partner, CciO, a 2-oxoglutarate/Fe-dependent oxygenase, in Cu resistance.
View Article and Find Full Text PDFTheranostics
March 2025
Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China 410008.
Acute high intraocular pressure (IOP) induces retinal ischemia/reperfusion (RI/R) that further initiates neuroinflammatory responses. This event can cause retinal tissue damage and neuronal death, ultimately resulting in irreversible blindness worldwide that lacks effective therapies, validated treatment targets and underlying mechanisms. We sought to explore the potential mechanisms on the causal link between the neuroinflammatory response and neurodegeneration following acute high IOP.
View Article and Find Full Text PDFInt J Biol Sci
March 2025
111 Project Laboratory of Biomechanics and Tissue Repair & Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Empirical evidence indicates that the rate of wound healing varies through different seasons, where it is higher in spring and fall but lower in summer and winter, suggesting adequate temperatures may promote wound healing via an unknown mechanism. Here we show that adequate temperature facilitates wound healing by inducing the expression of Elongation of Very Long Chain Fatty Acid Elongase 4 (ELOVL4) that curtails the inflammation phase. Using skin injury and skin organoids models, bulk- and single-cell RNA-sequencing and spatial transcriptomics analysis, and functional perturbations, we first demonstrate that adjusting skin surface temperature to 20°C by contact cooling markedly increases the rate of wound healing via upregulating ELOVL4 in the injured epidermis.
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