AI Article Synopsis
- The study aimed to explore the link between clinical and pathological features in patients with IgA nephropathy, focusing on those with and without IgG deposition in the kidneys.
- Data were collected from 122 patients diagnosed with IgA nephropathy, categorized into two groups based on IgG presence, and analyzed using various microscopy techniques.
- Results indicated that patients with IgG deposition experienced worse clinical symptoms and more significant kidney damage, suggesting the need for targeted interventions to manage IgG levels in these patients.
Article Abstract
Objective: To investigate the relationship between the clinical and pathological findings in IgA nephropathy with or without IgG deposition in the glomerular mesangial area.
Methods: The data were collected from 122 patients with a diagnosis of IgA nephropathy by renal biopsy in the Third Affiliated Hospital of Southern Medical University between November, 2009 and February, 2016. All the samples were examined by light microscopy, immunofluorescence and electron microscopy. According to the results of immunofluorescence assay, the patients were divided into IgA group (n=63) and IgA-IgG group (n=59). The pathological classification of IgA nephropathy was analyzed according to Oxford classification and Lee's classification. The clinical and pathological findings were compared between the two groups.
Results: Compared with the patients with IgA nephropathy but without IgG deposition, patients with IgA nephropathy with IgG deposition had higher serum creatinine, higher 24-h urine protein, higher blood uric acid, higher triglyceride levels (P<0.05) and lower eGFR (P<0.05); more of these patients were in Lee's grade IV-V, had renal tubular atrophy and/or interstitial fibrosis, and had MEST scores more than 3 (P<0.05).
Conclusion: Patients with IgA nephropathy with IgG deposition in the glomerular mesangial have severer clinical symptoms and more serious pathological changes. Measures should be taken to control IgG deposition in patients with IgA nephropathy to delay the progress of the disease.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780451 | PMC |
| http://dx.doi.org/10.3969/j.issn.1673-4254.2017.03.05 | DOI Listing |
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